Suppressor T cells in mice made unresponsive to skin allografts (original) (raw)

Nature volume 255, pages 489–491 (1975)Cite this article

Abstract

WE have established1 that long-lasting, strain-specific unresponsiveness to H-2 incompatible skin allografts can be induced in 30–50% of adult CBA mice by pretreatment with a single injection of a crude extract of liver from the graft donor strain, combined with a dose of Bordetella pertussis vaccine and a short course of antilymphocyte serum (ALS). Lymphoid cells removed from mice bearing healthy well-established allografts were reactive against graft donor strain antigens when tested in mixed lymphocyte culture (MLC), cell-mediated lympholysis tests (CML) and in graft versus host assays (G_v_H)2. Haemagglutinating and cytotoxic antibodies specific for the donor strain were invariably absent from the serum of unresponsive mice although small quantities of IgGl antibodies have been detected by a more sensitive technique3. We have so far been unable to detect any strain-specific suppressive activity in sera using MLC, CML and G_v_H tests2 or when passively transferring sera to skin-grafted mice.

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Author notes

  1. M. PINTO
    Present address: Israel Institute for Biological Research, POB 19, Ness-Ziona, Israel

Authors and Affiliations

  1. Department of Immunology, St Mary's Hospital Medical School, London, W2 1PG, UK
    P. J. KILSHAW, L. BRENT & M. PINTO

Authors

  1. P. J. KILSHAW
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  2. L. BRENT
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  3. M. PINTO
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KILSHAW, P., BRENT, L. & PINTO, M. Suppressor T cells in mice made unresponsive to skin allografts.Nature 255, 489–491 (1975). https://doi.org/10.1038/255489a0

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