γ-Aminobutyric acid in rat superior cervical ganglion (original) (raw)

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• Published: 08 April 1976

Nature volume 260, pages 540–541 (1976)Cite this article

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Abstract

RADIOLABELLED γ-aminobutyric acid (GABA) is taken up by both neurones and glial cells in the central nervous system1,2, where it mixes with endogenous GABA stores3. Superior cervical and dorsal root ganglia also accumulate radioactive GABA and this amino acid is taken up exclusively in satellite glial cells4,5. The presence of GABA in peripheral neural tissues has not, however, been demonstrated unequivocally6–8. We have measured GABA and glutamic acid in rat superior cervical and nodose ganglia by mass fragmentography. The concentration of GABA in nodose ganglia was lower than in the superior cervical sympathetic ganglion (SCG). Moreover, our results suggest that the content of GABA in the SCG may be controlled by neuronal activity.

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Author notes

1. AMIN SURIA
   Present address: Department of Pharmacology, George Washington University School of Medicine, Washington, DC, 20037

Authors and Affiliations

1. Laboratory of Preclinical Pharmacology, National Institutes of Mental Health, St Elizabeth's Hospital, Washington, DC, 20032
   LEIF BERTILSSON, AMIN SURIA & ERMINIO COSTA

Authors

1. LEIF BERTILSSON
2. AMIN SURIA
3. ERMINIO COSTA

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BERTILSSON, L., SURIA, A. & COSTA, E. γ-Aminobutyric acid in rat superior cervical ganglion.Nature 260, 540–541 (1976). https://doi.org/10.1038/260540a0

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• Received: 05 January 1976
• Accepted: 10 February 1976
• Issue date: 08 April 1976
• DOI: https://doi.org/10.1038/260540a0

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