Much IDO about pregnancy (original) (raw)

Nature Medicine volume 4, pages 1128–1129 (1998) Cite this article

Abstract

A recent study suggests that immunosuppression mediated by IDO, an enzyme that catabolizes tryptophan, may prevent rejection of the fetus by the maternal immune system.

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References

  1. Medawar, P.B. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp. for the Soc. Exp. Biol. 7, 320 (1954).
    Google Scholar
  2. Munn, D.H. et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281, 1191–1193 (1998).
    Article CAS Google Scholar
  3. Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991–1045 ( 1994).
    Article CAS Google Scholar

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Acknowledgements

We heartily thank Dr. Melvyn Heyes for educating us about IDO and tryptophan.

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Authors and Affiliations

  1. Dept. of Gynecology and Obstetrics, Emory University Medical School, Atlanta, 30303, Georgia, USA
    Elizabeth A. Bonney
  2. Lab. of Cellular and Molecular Immunology, NIAID, NIH, Bethesda, 20892, Maryland, USA
    Polly Matzinger

Authors

  1. Elizabeth A. Bonney
  2. Polly Matzinger

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Bonney, E., Matzinger, P. Much IDO about pregnancy.Nat Med 4, 1128–1129 (1998). https://doi.org/10.1038/2624

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