Effect of plant cytokinins on microfilaments and tight junction permeability (original) (raw)

Nature volume 264, pages 666–668 (1976)Cite this article

Abstract

IN epithelia classified as “leaky”, net transport efficiency of NaCl and water may be determined not only by cellular metabolic activity, but also by tight junction permeability and the conjugate physical driving forces acting between lumen and intercellular space. The significance of paracellular ion movement across leaky epithelia would become more apparent if a cytoplasmic mechanism for regulation of tight junctional permeability could be defined. The structure–function observations reported here suggest that the microfilament system may have such a function. Rapid and reversible increases in shunt path electrical resistance were observed in Necturus gallbladder exposed to plant cytokinins. In electron micrographs zeiotic transformation of the luminal membrane was associated with disruption of microfilaments and in freeze fracture, with reorientation and disorder of tight junctional elements.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Frömter, E., J. Membr. Biol., 8, 259–301 (1972).
    Article Google Scholar
  2. van Os, C. H. and Slegers, J. F. G., J. Membr. Biol., 24, 341–363 (1975).
    Article CAS Google Scholar
  3. Reuss, L., and Finn, A. L., J. Membr. Biol., 25, 115–139 (1975).
    Article CAS Google Scholar
  4. Burgess, D. R., and Grey, R. D., J. Cell Biol., 62, 566–574 (1974).
    Article CAS Google Scholar
  5. Elias, P. M., and Friend, D. S., J. Cell Biol., 68, 173–188 (1976).
    Article CAS Google Scholar
  6. Montesano, R., Gabbiani, G., Perrelet, A., and Orci, L., J. Cell Biol., 68, 793–798 (1976).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Microscopie Electronique, Institut de Biologie Moleculaire du CNRS et de l' Universite Paris VII,
    C. J. BENTZEL, B. HAINAU, A. EDELMAN, T. ANAGNOSTOPOULOS & E. L. BENEDETTI
  2. Hôpital des Enfants Malades, Paris, France
    C. J. BENTZEL, B. HAINAU, A. EDELMAN, T. ANAGNOSTOPOULOS & E. L. BENEDETTI

Authors

  1. C. J. BENTZEL
    You can also search for this author inPubMed Google Scholar
  2. B. HAINAU
    You can also search for this author inPubMed Google Scholar
  3. A. EDELMAN
    You can also search for this author inPubMed Google Scholar
  4. T. ANAGNOSTOPOULOS
    You can also search for this author inPubMed Google Scholar
  5. E. L. BENEDETTI
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

BENTZEL, C., HAINAU, B., EDELMAN, A. et al. Effect of plant cytokinins on microfilaments and tight junction permeability.Nature 264, 666–668 (1976). https://doi.org/10.1038/264666a0

Download citation