Stable variants affecting B cell alloantigens in human lymphoid cells (original) (raw)

Nature volume 271, pages 459–461 (1978)Cite this article

Abstract

THE human major histocompatibility complex (MHC) is defined by four loci: HLA-A, B and C are serologically defined and HLA-D was initially defined by the mixed lymphocyte reaction (MLR)1. There is now evidence that a group of HLA-linked, serologically defined B cell-specific alloantigens are the gene products of either the D locus itself or of closely linked genes2,3. Strong associations are seen between alleles of HLA-D and the B cell-specific genotypes, and B cell antisera inhibit the MLR4,5. The _D_-associated antigens differ from the products of HLA-A, B and C in chemical structure and in tissue distribution6. Human B-cell alloantigens resemble Ia antigens in mice. Analysis of the relationships among Ia antigens, MLC loci and other functions mapping in the I region is limited in both humans and mice by the availability of recombinant individuals7. Because such recombinants are rare, we have begun an analysis of this region by mutation8, using immuno-selection to isolate mutants defective for MHC gene products in human lymphoid cell lines. We describe here the first Ia variants to be isolated and characterised in any species.

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Authors and Affiliations

  1. Department of Pediatrics RD-20, School of Medicine, University of Washington, Seattle, Washington, 98195
    PAUL GLADSTONE & DONALD PIOUS

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  1. PAUL GLADSTONE
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  2. DONALD PIOUS
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GLADSTONE, P., PIOUS, D. Stable variants affecting B cell alloantigens in human lymphoid cells.Nature 271, 459–461 (1978). https://doi.org/10.1038/271459a0

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