Cell-mediated immunity in the liver of mice vaccinated against malaria (original) (raw)

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• Published: 13 December 1979

Nature volume 282, pages 731–734 (1979)Cite this article

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Abstract

Mice can be protected against several species of lethal malaria infection by vaccination1, and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin3–5, although there is no obvious explanation for this effect. We now report an apparent relationship between protection and a cell-mediated immune response involving the migration of various types of cell capable of killing malaria parasites in vitro to the liver. We suggest that the effect of vaccination is to bring together parasites, specific antibody and nonspecific cytotoxic cells, and that the liver may be a major site for their interaction.

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References

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Authors and Affiliations

1. Department of Immunology, Middlesex Hospital Medical School, London, W1, UK
   J. H. L. Playfair, J. B. De Souza, H. M. Dockrell, P. U. Agomo & J. Taverne

Authors

1. J. H. L. Playfair
2. J. B. De Souza
3. H. M. Dockrell
4. P. U. Agomo
5. J. Taverne

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Playfair, J., De Souza, J., Dockrell, H. et al. Cell-mediated immunity in the liver of mice vaccinated against malaria.Nature 282, 731–734 (1979). https://doi.org/10.1038/282731a0

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• Received: 15 May 1979
• Accepted: 16 October 1979
• Issue date: 13 December 1979
• DOI: https://doi.org/10.1038/282731a0

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