The joining of V and J gene segments creates antibody diversity (original) (raw)
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- Published: 31 January 1980
Nature volume 283, pages 497–499 (1980)Cite this article
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Abstract
The variable regions of mouse kappa (κ) chains are coded for by multiple variable (V) gene segments and multiple joining (J) gene segments. The Vκ gene segments code for residues 1 to 95; the Jκ gene segments code for residues 96 to 108 (refs 1–3). This gene organisation is similar to that encoding the Vλ regions4. Diversity in Vκ regions arises from several sources: (1) there are multiple germ-line Vκ gene segments and Jκ gene segments; (2) combinatorial joining of Vκ gene segments with different germ-line Jκ gene segments; and possibly, (3) somatic point mutation, as postulated for Vλ gene segments5. Also, from a comparison of the number of germ-line Jκ gene segments and amino acid sequences, it has been suggested that Jκ region sequences may be determined by the way Vκ and Jκ gene segments are joined2,3. This report supports this model by directly associating various Jκ sequences with given Jκ gene segments.
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Authors and Affiliations
- The Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111
Martin Weigert, Robert Perry & Dawn Kelley - California Institute of Technology, Division of Biology, Pasadena, California, 91125
Tim Hunkapiller, James Schilling & Leroy Hood
Authors
- Martin Weigert
You can also search for this author inPubMed Google Scholar - Robert Perry
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You can also search for this author inPubMed Google Scholar - Tim Hunkapiller
You can also search for this author inPubMed Google Scholar - James Schilling
You can also search for this author inPubMed Google Scholar - Leroy Hood
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Weigert, M., Perry, R., Kelley, D. et al. The joining of V and J gene segments creates antibody diversity.Nature 283, 497–499 (1980). https://doi.org/10.1038/283497a0
- Received: 04 September 1979
- Accepted: 11 November 1979
- Issue Date: 31 January 1980
- DOI: https://doi.org/10.1038/283497a0