Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone (original) (raw)

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• Published: 14 February 1980

Nature volume 283, pages 673–676 (1980)Cite this article

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Abstract

Cholinergic excitation of vertebrate neurones is frequently mediated through the action of acetylcholine on muscarinic (atropine-sensitive) receptors. This type of excitation differs substantially from the better known nicotinic excitation. One difference is that, instead of an increased membrane conductance, a decreased conductance (to K+ ions) frequently accompanies muscarinic depolarisation. This has been detected in sympathetic1–4, cortical5 and hippocampal6 neurones. Using voltage-clamped frog sympathetic neurones we have now identified a distinctive voltage-sensitive K+ -current, separate from the delayed rectifier current, as the prime target for muscarinic agonists. We have termed this current the M-current, _I_M.

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References

1. Kobayashi, H. & Libet, B. Proc. natn. Acad. Sci. U.S.A. 60, 1304–1311 (1968).
   Article ADS CAS Google Scholar
2. Weight, F. & Votava, J. Science 170, 755–758 (1970).
   Article ADS CAS Google Scholar
3. Kuba, K. & Koketsu, K. Jap. J. Physiol. 26, 651–669 (1976).
   Article CAS Google Scholar
4. Kuba, K. & Koketsu, K. Jap. J. Physiol. 26, 703–716 (1976).
   Article CAS Google Scholar
5. Krnjevic, K., Pumain, R. & Renaud, L. J. Physiol., Lond. 215, 247–268 (1971).
   Article CAS Google Scholar
6. Dingledine, R., Dodd, J. & Kelly, J. S. J. Physiol., Lond. 273, 79–80P (1977).
   Google Scholar
7. Connor, J. A. & Stevens, C. F. J. Physiol., Lond. 213, 21–30 (1971).
   Article CAS Google Scholar
8. Thompson, S. J. Physiol., Lond. 265, 465–488 (1977).
   Article ADS CAS Google Scholar
9. Hodgkin, A. L. & Huxley, A. F. J. Physiol., Lond. 117, 500–544 (1952).
   Article CAS Google Scholar
10. Brown, D. A. & Fatherazi, S. Br. J. Pharmac. 59, 500–501P (1976).
    Google Scholar
11. Brown, D. A. & Constanti, A. Brain Res. (in the press).
12. Kuba, K. & Koketsu, K. Brain Res. 137, 381–386 (1977).
    Article CAS Google Scholar
13. Brown, H. F., Giles, W. & Noble, S. J. J. Physiol., Lond. 271, 783–816 (1977).
    Article CAS Google Scholar

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Authors and Affiliations

1. Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas, 77550
   D. A. Brown & P. R. Adams
2. Department of Pharmacology. The School of Pharmacy, University of London, 29–39 Brunswick Square, London, WC1N 1AX
   D. A. Brown

Authors

1. D. A. Brown
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2. P. R. Adams
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Brown, D., Adams, P. Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone.Nature 283, 673–676 (1980). https://doi.org/10.1038/283673a0

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• Received: 05 October 1979
• Accepted: 13 December 1979
• Issue Date: 14 February 1980
• DOI: https://doi.org/10.1038/283673a0

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