FYVE fingers bind PtdIns(3)P (original) (raw)

• Scientific Correspondence
• Published: 30 July 1998
• Anne Simonsen1,
• Antonello D'Arrigo,
• Bjørn Bremnes,
• Harald Stenmark1 &
• …
• Rein Aasland2

Nature volume 394, pages 432–433 (1998)Cite this article

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Abstract

The membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) is constitutively produced by yeast and higher eukaryotes through the phosphorylation of phosphatidylinositol by phosphatidylinositol-3-OH kinase1 (PI(3)K). PtdIns(3)P is important for vesicular transport1, but little is known about how it acts, and proteins that specifically recognize it have not yet been identified. Here we identify the FYVE finger2, an evolutionarily conserved double-zinc-binding domain (see Supplementary information), as a protein structure that binds to PtdIns(3)P with high specificity.

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References

1. Toker, A. & Cantley, L. C. Nature 387, 673–676 (1997).
   Article ADS CAS Google Scholar
2. Stenmark, H., Aasland, R., Toh, B. H. & D'Arrigo, A. J. Biol. Chem. 271, 24048–24054 (1996).
   Google Scholar
3. Mu, F. T.et al. J. Biol. Chem. 270, 13503–13511 (1995).
   Google Scholar
4. Patki, V., Virbasius, J., Lane, W. S., Toh, B. H., Shpetner, H. S. & Corvera, S. Proc. Natl Acad. Sci. USA 94, 7326–7330 (1997).
   Google Scholar
5. Simonsen, A.et al. Nature 394, 494–498 (1998).
   Article ADS CAS Google Scholar
6. Komada, M., Masaki, R., Yamamoto, A. & Kitamura, N. J. Biol. Chem. 272, 20538–20544 (1997).
   Google Scholar
7. Schiavo, G., Gu, Q.-M., Prestwich, G. D., Söllner, T. H. & Rothman, J. E. Proc. Natl Acad. Sci. USA 93, 13327–13332 (1996).
   Google Scholar
8. Shirataki, H.et al. Mol. Cell. Biol. 13, 2061–2068 (1993).
   Google Scholar
9. Patki, V., Virbasius, J. V., Chawla, A., Lawe, D. C. & Corvera, S. Nature 394, 433–434 (1998).
   Article ADS CAS Google Scholar
10. Piper, R. C., Cooper, A. A., Yang, H. & Stevens, T. H. J. Cell Biol. 131, 603–617 (1995).
    Google Scholar
11. Burd, C. G., Peterson, M., Cowles, C. R. & Emr, S. D. Mol. Biol. Cell 8, 1089–1104 (1997).
    Google Scholar
12. Dove, S. K.et al. Nature 390, 187–192 (1997).
    Article ADS CAS Google Scholar

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Authors and Affiliations

1. Department of Biochemistry, The Norwegian Radium Hospital, N-0310, Oslo, Norway
   Jean-Michel Gaullier, Anne Simonsen & Harald Stenmark
2. Department of Molecular Biology, University of Bergen, Bergen, N-5020, Norway
   Rein Aasland

Authors

1. Jean-Michel Gaullier
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2. Anne Simonsen
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3. Antonello D'Arrigo
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4. Bjørn Bremnes
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5. Harald Stenmark
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6. Rein Aasland
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Gaullier, JM., Simonsen, A., D'Arrigo, A. et al. FYVE fingers bind PtdIns(3)P.Nature 394, 432–433 (1998). https://doi.org/10.1038/28767

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• Issue Date: 30 July 1998
• DOI: https://doi.org/10.1038/28767