Proteases — invasion and more (original) (raw)

Cancer

Nature volume 394, pages 527–528 (1998)Cite this article

The June AACR/APMIS conferenceFootnote 1on ‘proteases and protease inhibitors in cancer’ provided an opportunity to take a good look at the importance of these proteins in cancer biology, particularly for functions other than cellular invasion1. The conference came at an appropriate time, with booming interest in angiogenesis (the formation of new blood vessels) as a therapeutic target and with first-generation synthetic matrix metalloproteinase inhibitors (MMPIs), such as British Biotech's marimastat, hitting the clinic. The emerging picture is that some questions — such as what individual proteases and inhibitors do during tumorigenesis, and whether this information is useful in prognosis or therapy — may soon be answered.

*Proteases and Protease Inhibitors in Cancer, held by the American Association for Cancer Research and ACTA Pathologica Microbiologica Immunologica Scandinavia, Nyborg Strand Hotel, Nyborg, Denmark, 14-18 June 1998.

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Figure 1: Interactions between tumour and stromal cells, and the regulation of proteases and protease inhibitors.

Notes

  1. *Proteases and Protease Inhibitors in Cancer, held by the American Association for Cancer Research and ACTA Pathologica Microbiologica Immunologica Scandinavia, Nyborg Strand Hotel, Nyborg, Denmark, 14-18 June 1998.

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Authors and Affiliations

  1. School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, Norfolk, UK
    Dylan R. Edwards & Gillian Murphy

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  1. Dylan R. Edwards
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  2. Gillian Murphy
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Edwards, D., Murphy, G. Proteases — invasion and more.Nature 394, 527–528 (1998). https://doi.org/10.1038/28961

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