C-terminal sequence of the secreted form of mouse IgD heavy chain (original) (raw)
- Letter
- Published: 02 July 1981
Nature volume 292, pages 61–63 (1981)Cite this article
Abstract
Immunoglobulins have been identified as membrane-bound molecules on the surface of B lymphocytes and as secreted products of plasma cells. In the case of immunoglobulin M(IgM) the carboxy-terminal sequences of the μ-chains of membrane-bound and secreted molecules differ from each other and are encoded by different exons of the μ constant region (Cμ) gene. The coding sequence for the C-terminus of the secreted μ-chain is contiguous with the 3′ end of the Cμ4 exon and separate exons downstream of Cμ4 encode the C-terminus of the membrane-bound chain1–3. Immunoglobulin D is also found membrane-bound and as a secreted molecule, and recent data indicate that the exon arrangement of the Cδ gene is in part similar to that of the Cμ gene4,5. However, the amino acid sequence analysis presented here demonstrates that in the case of IgD the C-terminus of the secreted δ-chain is encoded by a separate exon (the CδDC exon of Tucker _et al._5) and not by the CδAC sequence which corresponds topographically to the sequence expressed at the C-terminus of secreted μ chains.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Singer, P. A., Singer, H. H. & Williamson, A. R. Nature 285, 294–300 (1980).
Article CAS ADS Google Scholar - Rogers, J. et al. Cell 20, 303–312 (1980).
Article CAS Google Scholar - Early, P. et al. Cell 20, 313–319 (1980).
Article CAS Google Scholar - Liu, C., Tucker, P. W., Mushinski, J. F. & Blattner, F. R. Science 209, 1348–1352 (1980).
Article CAS ADS Google Scholar - Tucker, P. W., Liu, C., Mushinski, J. F. & Blattner, F. R. Science 209, 1353–1360 (1980).
Article CAS ADS Google Scholar - Neuberger, M. S. & Rajewsky, K. Proc. natn. Acad. Sci. U.S.A. 78, 1138–1142 (1981).
Article CAS ADS Google Scholar - Kehry, M., Sibley, C., Fuhrman, J., Schilling, J. & Hood, L. E. Proc. natn. Acad. Sci. U.S.A. 76, 2932–2936 (1979).
Article CAS ADS Google Scholar - Tucker, P. W. et al. in The Lymphocytes in the Immune Response (eds Mosier, D., Klinman N., Sher, E. & Vitetta, E.) (Elsevier, Amsterdam, in the press).
- Waxdal, M. J., Konigsberg, W. H., Henley, W. L. & Edelman, G. M. Biochemistry 7, 1959–1966 (1968).
Article CAS Google Scholar - Bray, G. Analyt. Biochem. 1, 279–285 (1960).
Article CAS Google Scholar - Bothwell, A. L. M. et al. Cell (in the press).
- Tarr, G. E., Beecher, J. F., Bell, M. & McKean, D. J. Analyt. Biochem. 84, 622–627 (1978).
Article CAS Google Scholar - Beyreuther, K., Raufuss, H., Schrecker, O. & Hengstenberg, W. Eur. J. Biochem. 75, 275–286 (1977).
Article CAS Google Scholar - Johnson, N. D., Hunkapiller, M. W. & Hood, L. E. Analyt. Biochem. 100, 335–338 (1979).
Article CAS Google Scholar - Beyreuther, K. in Solid Phase Methods in Protein Sequence Analysis, 107–119 (Elsevier, Amsterdam, 1977).
Google Scholar - Dayhoff, M. Atlas of Protein Sequence and Structure Vol. 5, D2 (National Biomedical Research Foundation, Washington, 1972).
Google Scholar
Author information
Authors and Affiliations
- Institut für Genetik der Universität zu Köln, D-5000, Köln, 41, FRG
Renate Dildrop & Konrad Beyreuther
Authors
- Renate Dildrop
You can also search for this author inPubMed Google Scholar - Konrad Beyreuther
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Dildrop, R., Beyreuther, K. C-terminal sequence of the secreted form of mouse IgD heavy chain.Nature 292, 61–63 (1981). https://doi.org/10.1038/292061a0
- Received: 12 February 1981
- Accepted: 28 April 1981
- Issue Date: 02 July 1981
- DOI: https://doi.org/10.1038/292061a0