Family studies define a new histocompatibility locus, SB, between HLA-DR and GLO (original) (raw)

Nature volume 293, pages 745–747 (1981)Cite this article

Abstract

Gene products of the human HLA region are the principal histocompatibility barrier to human allogeneic tissue transplantation1. In addition, HLA genes regulate immune responses to environmental antigens2 and affect susceptibility to various diseases3. Although the HLA region has been studied intensively, only four histocompatibility loci (_HLA_-A, -B, -C and -DR) have been identified within this ‘supergene’, but the existence of additional loci has been suggested by immunochemical4–9 and genetic recombination10–15 studies. Recently, a new segregant series of five histocompatibility antigens, named ‘Secondary B cell’ (SB) antigens, was defined16–18. We now report studies of 21 families which indicate that the gene encoding the SB antigens is closely linked to HLA-DR, but is distinguished from it by recombination in two families and can be mapped between HLA-DR and GLO in additional recombinant families.

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References

  1. Morris, P. J., Batchelor, J. R. & Festenstein, H. Br. med. Bull. 34, 259–262 (1978).
    Article CAS Google Scholar
  2. Munro, A. & Waldmann, H. Br. med. Bull. 34, 253–258 (1978).
    Article CAS Google Scholar
  3. Dausset, J. & Svejgaard, A. (eds) HLA and Disease (Munksgaard, Copenhagen, 1977).
  4. Tosi, R. N. et al. J. exp. Med. 148, 1592–1611 (1978).
    Article CAS Google Scholar
  5. Lampson, L. A. & Levy, R. J. Immun. 125, 293–299 (1980).
    CAS PubMed Google Scholar
  6. Charron, D. C. & McDevitt, H. O. Proc. natn. Acad. Sci. U.S.A. 76, 6567–6571 (1979).
    Article ADS CAS Google Scholar
  7. Shackleford, D. A. & Strominger, J. L. J. exp. Med. 151, 144–165 (1980).
    Article Google Scholar
  8. Market, M. L. & Cresswell, P. Proc. natn. Acad. Sci. U.S.A. 77, 6101–6104 (1980).
    Article ADS Google Scholar
  9. Nadler, L. M. et al. Nature 290, 591–593 (1981).
    Article ADS CAS Google Scholar
  10. Mawas, C., Charmot, D. & Mercier, P. Tissue Antigens 15, 458–466 (1980).
    Article CAS Google Scholar
  11. Mawas, C. E. et al. J. Immunogenet. 5, 383–395 (1978).
    Article CAS Google Scholar
  12. Reinsmoen, N. L. et al. Tissue Antigens 13, 19–34 (1979).
    Article CAS Google Scholar
  13. Segall, M., Reinsmoen, N. L., Noreen, H. J. & Bach, F. H. J. exp. Med. 152, 156s–163s (1980).
    CAS PubMed Google Scholar
  14. Park, M. S. & Terasaki, P. I. in Histocompatibility Testing, 1980 (ed. Terasaki, P. I.) (UCLA Press, Los Angeles, 1980).
    Google Scholar
  15. Sachs, J. A., Jaraquemada, D. & Festenstein, H. Tissue Antigens 17, 43–56 (1981).
    Article CAS Google Scholar
  16. Shaw, S., Johnson, A. H. & Shearer, G. M. J. exp. Med 152, 565–580 (1980).
    Article CAS Google Scholar
  17. Shaw, S., Pollack, M. S., Payne, S. M. & Johnson, A. H. Hum. Immun., 1, 177–185 (1980).
    Article CAS Google Scholar
  18. Shaw, S., Duquesnoy, J. & Smith, P. L. Immunogenetics (in the press).
  19. Kavathas, P., DeMars, R., Bach, F. H. & Shaw, S. Nature 293, 747–749 (1981).
    Article ADS CAS Google Scholar
  20. Shaw, S., O'Neill, G. J. & Shearer, G. M. Transplantn Proc. 11, 1804–1808 (1979).
    CAS Google Scholar
  21. Termijtelen, A., Bradley, B. A. & Van Rood, J. J. Tissue Antigens 15, 267–274 (1980).
    Article CAS Google Scholar

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Authors and Affiliations

  1. Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA
    Stephen Shaw
  2. Department of Genetics, Stanford University, Stanford, California, 94305, USA
    Paula Kavathas
  3. Tissue Typing Laboratory, Sloan-Kettering Memorial Institute for Cancer Research, New York, New York, 10021, USA
    Marilyn S. Pollack
  4. Centre d'Immunologie INSERM-CRNS de Marseille-Luminy, Marseille, France
    Dominique Charmot & Claude Mawas

Authors

  1. Stephen Shaw
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  2. Paula Kavathas
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  3. Marilyn S. Pollack
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  4. Dominique Charmot
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  5. Claude Mawas
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Shaw, S., Kavathas, P., Pollack, M. et al. Family studies define a new histocompatibility locus, SB, between HLA-DR and GLO.Nature 293, 745–747 (1981). https://doi.org/10.1038/293745a0

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