Vasoactive intestinal polypeptide enhances muscarinic ligand binding in cat submandibular salivary gland (original) (raw)

Nature volume 295, pages 147–149 (1982)Cite this article

Abstract

The salivary secretion from the cat submandibular salivary gland induced by parasympathetic nerve stimulation is considered to be due to release of acetylcholine (ACh) which binds to muscarinic receptors and activates secretory elements1. Recent evidence suggests that cholinergic neurones in the cat submandibular gland contain and release another neurotransmitter candidate, vasoactive intestinal polypeptide (VIP)2,3. Although VIP per se does not induce salivary secretion, it potentiates the secretion induced by ACh infusions2,3. The present study offers a possible explanation for this potentiation by showing that VIP in physiologically relevant concentrations enhances the binding of muscarinic cholinergic ligands in the cat submandibular gland.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Babkin, B. P. Secretory Mechanism of the Digestive Glands 2nd edn (Hoeber, New York, 1950).
    Google Scholar
  2. Lundberg, J. M., Änggård, A., Fahrenkrug, J., Hökfelt, T. & Mutt, V. Proc. natn. Acad. Sci. U.S.A. 77, 1651–1655 (1980).
    Article ADS CAS Google Scholar
  3. Lundberg, J. M. Acta physiol. scand. 112, Suppl. 496, 1–57 (1981).
    Article Google Scholar
  4. Hedlund, B. & Bartfai, T. Molec. Pharmac. 15, 531–544 (1979).
    CAS Google Scholar
  5. Kloog, Y. & Sokolovsky, M. Brain Res. 144, 31–48 (1978).
    Article CAS PubMed Google Scholar
  6. Järv, J., Hedlund, B. & Bartfai, T. J. biol. Chem. 255, 5595–5598 (1979).
    Google Scholar
  7. Domschke, S. et al. Gut 19, 1049–1053 (1978).
    Article CAS PubMed PubMed Central Google Scholar
  8. Keltz, T. N., Straus, E. & Yalow, R. S. Biochem. biophys. Res. Commun. 92, 669–674 (1980).
    Article CAS PubMed Google Scholar
  9. Birdsall, N. J. M., Burgen, A. S. V. & Hulme, E. C. Molec. Pharmac. 14, 723–736 (1978).
    CAS Google Scholar
  10. Birdsall, N. J. M. & Hulme, E. C. J. Neurochem. 27, 7–16 (1976).
    Article CAS PubMed Google Scholar
  11. Heilbronn, E. & Bartfai, T. Prog. Neurobiol. 11, 171–188 (1978).
    Article CAS PubMed Google Scholar
  12. Parod, R. J., Leslie, B. A. & Putney, J. W. Am. J. Physiol. 239, G99–G105 (1980).
    CAS PubMed Google Scholar
  13. Putney, J. W., Landis, C. A. & van de Walle, C. M. Pflügers Arch. ges. Physiol. 385, 131–138 (1980).
    Article CAS Google Scholar
  14. Putney, J. W. & Parod, R. J. J. Pharmac. exp. Ther. 205, 449–458 (1978).
    CAS Google Scholar
  15. Watanabe, A. M. et al. J. biol. Chem. 253, 4833–4836 (1978).
    CAS PubMed Google Scholar
  16. Kumakura, K., Karoum, F., Guidotti, A. & Costa, E. Nature 283, 489–492 (1980).
    Article ADS CAS PubMed Google Scholar
  17. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. J. biol. Chem. 193, 265–275 (1951).
    CAS PubMed Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Karolinska Institutet, Fack, S-104 01, Stockholm, Sweden
    Jan M. Lundberg
  2. Deprtment of Biochemistry, University of Stockholm, Arrhenius Laboratory, S-106 91, Stockholm, Sweden
    Britta Hedlund & Tamas Bartfai

Authors

  1. Jan M. Lundberg
    You can also search for this author inPubMed Google Scholar
  2. Britta Hedlund
    You can also search for this author inPubMed Google Scholar
  3. Tamas Bartfai
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Lundberg, J., Hedlund, B. & Bartfai, T. Vasoactive intestinal polypeptide enhances muscarinic ligand binding in cat submandibular salivary gland.Nature 295, 147–149 (1982). https://doi.org/10.1038/295147a0

Download citation

This article is cited by