Vasoactive intestinal polypeptide enhances muscarinic ligand binding in cat submandibular salivary gland (original) (raw)
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- Published: 14 January 1982
Nature volume 295, pages 147–149 (1982)Cite this article
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Abstract
The salivary secretion from the cat submandibular salivary gland induced by parasympathetic nerve stimulation is considered to be due to release of acetylcholine (ACh) which binds to muscarinic receptors and activates secretory elements1. Recent evidence suggests that cholinergic neurones in the cat submandibular gland contain and release another neurotransmitter candidate, vasoactive intestinal polypeptide (VIP)2,3. Although VIP per se does not induce salivary secretion, it potentiates the secretion induced by ACh infusions2,3. The present study offers a possible explanation for this potentiation by showing that VIP in physiologically relevant concentrations enhances the binding of muscarinic cholinergic ligands in the cat submandibular gland.
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Authors and Affiliations
- Department of Pharmacology, Karolinska Institutet, Fack, S-104 01, Stockholm, Sweden
Jan M. Lundberg - Deprtment of Biochemistry, University of Stockholm, Arrhenius Laboratory, S-106 91, Stockholm, Sweden
Britta Hedlund & Tamas Bartfai
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- Jan M. Lundberg
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Lundberg, J., Hedlund, B. & Bartfai, T. Vasoactive intestinal polypeptide enhances muscarinic ligand binding in cat submandibular salivary gland.Nature 295, 147–149 (1982). https://doi.org/10.1038/295147a0
- Received: 03 June 1981
- Accepted: 06 November 1981
- Issue Date: 14 January 1982
- DOI: https://doi.org/10.1038/295147a0