Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma (original) (raw)

Nature volume 298, pages 474–476 (1982)Cite this article

Abstract

Burkitt's-type lymphomas–leukaemias (BL) are monoclonal proliferations of malignant B lymphocytes1. Irrespective of whether they carry the Epstein–Barr virus (EBV) genome, these tumour cells have been shown consistently to have one of the specific reciprocal chromosome translocations, t(8; 14), t(2; 8) or t(8; 22), involving the long arm of chromosome 8 (on 8q24) and chromosome 14,2 or 22 (on 14q32,2p12 and 22q11, respectively) 2–6. The latter chromosomes have been shown recently to carry genes for immunoglobulin (Ig) heavy chains7,8, and κ 9 and λ 10,11 light chains, respectively. Furthermore, the localization of κ light chains within 2pcen–2p13 encompasses the breakpoint observed in Burkitt's translocation (2p12). It was therefore considered of interest to determine whether the expression of immunoglobulin chains in BL cells is related to the type of chromosomal anomalies observed. We report here that there is a direct relationship between expression of immunoglobulin light chains and specific type of translocation: BL cells with t(8; 22) express λ chains, whereas those with t(2; 8) express κ chains.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

Burkitt lymphoma

Article 15 December 2022

References

  1. Preud'homme, J. L., Brouet, J. C., Danon, F., Flandrin, G. & Schaison, G. J. natn. Cancer Inst. 66, 261–264 (1981).
    CAS Google Scholar
  2. Zech, L., Haglund, U., Nilsson, K. & Klein, G. Int. J. Cancer 17, 47–56 (1976).
    Article CAS Google Scholar
  3. Van den Berghe, H. et al. Cancer Genet. Cytogenet. 1, 9–14 (1979).
    Article Google Scholar
  4. Miyoshi, I., Hiraki, S., Kimura, I., Miyamoto, K. & Sato, J. Experientia 35, 742 (1979).
    Article CAS Google Scholar
  5. Berger, R. et al. Hum. Genet. 53, 111–112 (1979).
    Article ADS CAS Google Scholar
  6. Bernheim, A., Berger, R. & Lenoir, G. C.r. hebd. Séanc. Acad. Sci., Paris 291, 237–239 (1980).
    CAS Google Scholar
  7. Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 76, 3416–3419 (1979).
    Article ADS CAS Google Scholar
  8. Hobart, M. J. et al. Ann. hum. Genet. 45, 331–335 (1981).
    Article CAS Google Scholar
  9. Malcolm, S. et al. 6th Int. Workshop on Human Gene Mapping, Oslo, 29 June–3 July (National Foundation-March of Dimes, New York, 1981).
  10. McBride, O. W., Swan, D., Leder, P., Hieter, P. & Hollis, G. 6th Int. Workshop on Human Gene Mapping, Oslo, 29 June–3 July (National Foundation-March of Dimes, 1981).
  11. Erikson, J., Martinis, J. & Croce, C. M. Nature 294, 173–175 (1981).
    Article ADS CAS Google Scholar
  12. I.C.S.N. An Int. System for Human Cytogenetics Nomenclature. Birth Defects Original Article Ser., Vol. 14, 8 (1978).
  13. Preud'homme, J. L. & Labaume, S. in In vitro Methods in Cell-mediated and Tumor Immunity (eds Bloom, B.R. & David, J. J.) 155–169 (Academic, New York, 1976).
    Google Scholar
  14. Miyoshi, I. et al. New Engl. J. Med. 304, 734 (1981).
    CAS PubMed Google Scholar
  15. Tanzer, J., Frocrain, C., Alcalay, D. & Desmaret, M. C. Nouv. Revue fr. Hemat. 22, Suppl., 107 (1980).
    Google Scholar
  16. Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).
    Article ADS CAS Google Scholar
  17. Wiener, F., Babonits, M., Spira, J., Klein, G. & Potter, M. Somatic Cell Genet. 6, 731–738 (1980).
    Article CAS Google Scholar
  18. Klein, G. Nature 294, 313–318 (1981).
    Article ADS CAS Google Scholar
  19. Philip, T. et al. Int. J. Cancer 28, 417–420 (1981).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, Cedex 2, France
    G. M. Lenoir
  2. Laboratory of Immunochemistry and Immunopathology, INSERM U 108, Hôpital St Louis, 75475, Paris, Cedex 10, France
    J. L. Preud'homme
  3. Laboratory of Immunology and Immunopathology, CHUR la Milétrie, 86021, Poitiers Cedex, France
    J. L. Preud'homme
  4. Laboratory of Cytogenetics, Institut de Recherches sur les Leucémies et Maladies du Sang, UER d'Hématologie, Hôpital St Louis, 2 place du Dr Fournier, 75475, Paris, Cedex 10, France
    A. Bernheim & R. Berger

Authors

  1. G. M. Lenoir
    You can also search for this author inPubMed Google Scholar
  2. J. L. Preud'homme
    You can also search for this author inPubMed Google Scholar
  3. A. Bernheim
    You can also search for this author inPubMed Google Scholar
  4. R. Berger
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Lenoir, G., Preud'homme, J., Bernheim, A. et al. Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma.Nature 298, 474–476 (1982). https://doi.org/10.1038/298474a0

Download citation

This article is cited by