Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5′ end of mRNA (original) (raw)

Nature volume 299, pages 221–226 (1982)Cite this article

Abstract

The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5′ end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5′ end of mRNA, appears to be important in determining initiation efficiency.

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Authors and Affiliations

  1. Department of Molecular Genetics, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
    Peter T. Lomedico & Stephen J. McAndrew

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  1. Peter T. Lomedico
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  2. Stephen J. McAndrew
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Lomedico, P., McAndrew, S. Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5′ end of mRNA.Nature 299, 221–226 (1982). https://doi.org/10.1038/299221a0

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