Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5′ end of mRNA (original) (raw)
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- Published: 16 September 1982
Nature volume 299, pages 221–226 (1982)Cite this article
Abstract
The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5′ end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5′ end of mRNA, appears to be important in determining initiation efficiency.
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Authors and Affiliations
- Department of Molecular Genetics, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
Peter T. Lomedico & Stephen J. McAndrew
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- Peter T. Lomedico
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Lomedico, P., McAndrew, S. Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5′ end of mRNA.Nature 299, 221–226 (1982). https://doi.org/10.1038/299221a0
- Received: 21 May 1982
- Accepted: 02 July 1982
- Issue Date: 16 September 1982
- DOI: https://doi.org/10.1038/299221a0