A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease (original) (raw)

Nature volume 302, pages 159–161 (1983)Cite this article

Abstract

Transplantation of bone marrow can give rise to graft-versus-host desease when donor T lymphocytes; mismatched with the host for major histocompatability (MHC) antigens, become sensitized and attack host tissues. However, graft-versus-host desease can also arise between donor and host with compatible MHC antigens but mismatched for a minor histocompatability antigen1–3. We report here on the occurrence of severe acute graft-versus-host disease in a male patient with acute myeloid leukaemia who had received bone marrow matched for MHC (HLA) antigens from his sister. Strong cytotoxicity of the post-transplantation (that is, donor) lymphocytes against the patient's pretransplantation lymphocytes was found. Thus, the transplanted lymphocytes differed in a non-HLA antigen from the patient. The possible role of this strong cytotoxic minor histocompatability antigen in the development of graft-versus-host disease in man is being evaluated. Furthermore, with the use of cytotoxic T-cell lines, derived from the patient's 6 day effector cells, we are now able to type for it before grafting.

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Authors and Affiliations

  1. Department of Immunohaematology and Blood Bank, University Hospital Leiden, Rijnsburgerweg 10, 2133 AA, Leiden, The Netherlands
    E. Goulmy, J. W. Gratama, E. Blokland & J. J. van Rood
  2. Isolation Pavilion, University Hospital Leiden, Rijnsburgerweg 10, 2133 AA, Leiden, The Netherlands
    F. E. Zwaan

Authors

  1. E. Goulmy
  2. J. W. Gratama
  3. E. Blokland
  4. F. E. Zwaan
  5. J. J. van Rood

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Goulmy, E., Gratama, J., Blokland, E. et al. A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease.Nature 302, 159–161 (1983). https://doi.org/10.1038/302159a0

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