A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium (original) (raw)

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• Published: 02 June 1983

Nature volume 303, pages 390–396 (1983)Cite this article

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Abstract

We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if cultured in the absence of serum. In certain culture conditions some of these cells acquire a mixed phenotype, displaying properties of both astrocytes and oligodendrocytes. These observations suggest that fibrous astrocytes and oligodendrocytes develop from a common progenitor cell and provide a striking example of developmental plasticity and environmental influence in the differentiation of CNS glial cells.

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Authors and Affiliations

1. Medical Research Council Neuroimmunology Project, Department of Zoology, University College London, London, WC1E 6BT, UK
   Martin C. Raff & Robert H. Miller
2. Institute of Neurology, Queen Square, London, WC1N 3BG, UK
   Mark Noble

Authors

1. Martin C. Raff
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2. Robert H. Miller
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3. Mark Noble
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Raff, M., Miller, R. & Noble, M. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium.Nature 303, 390–396 (1983). https://doi.org/10.1038/303390a0

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• Received: 17 January 1983
• Accepted: 30 March 1983
• Issue Date: 02 June 1983
• DOI: https://doi.org/10.1038/303390a0

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