Variable expression of Ia antigens on the vascular endothelium of mouse skin allografts (original) (raw)
- Letter
- Published: 02 June 1983
- M. J. J. Bogman1,
- C. N. Maass1,
- L. M. H. Cornelissen1,
- W. J. M. Tax1 &
- …
- R. A. P. Koene1
Nature volume 303, pages 426–429 (1983)Cite this article
- 41 Accesses
- 198 Citations
- Metrics details
Abstract
Ia antigens are membrane-bound glycoproteins that play a part in antigen recognition and subsequent cell–cell interactions in the immune response. In the mouse they are coded for by the I region of the major histocompatibility complex H–2 and have been demonstrated on B lymphocytes, monocytes, activated T cells, macrophages and dendritic cells, including Langerhans cells1,2. Ia-like antigens have also been detected on the vascular endothelium in man3–6 and on epidermal keratinocytes in rats7,8 but expression on the latter cells was induced by a graft-versus-host reaction or by contact hypersensitivity9. In the mouse, previous studies have suggested that Ia antigens in skin are restricted to epidermal Langerhans cells and it was thought that these were the targets for Ia-dependent rejection of skin allografts. The results presented here show that Ia antigens in mouse allografts are also present on the vascular endothelium but their expression is variable and dependent on the immunological status of the recipient. These findings suggest that vascular endothelial cells can act as targets in Ia-incompatible skin allograft rejection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Tamaki, K., Stingl, G., Gullino, M., Sachs, D. H. & Katz, S. I. J. Immun. 123, 784–787 (1979).
CAS PubMed Google Scholar - Rowden, G., Phillips, T. M. & Delovitch, T. L. Immunogenetics 7, 465–471 (1978).
Article CAS Google Scholar - Hirschberg, H., Moen, T. & Thorsby, E. Transplantation 28, 116–121 (1979).
Article CAS Google Scholar - Hayry, P., von Willebrand, E. & Anderson, L. C. Scand. J. Immun. 11, 303–310 (1980).
Article CAS Google Scholar - Natali, P. G., De Martino, C., Marcellini, M., Quaranta, V. & Ferrone, S. Clin. Immun. Immunopath. 20, 11–20 (1981).
Article CAS Google Scholar - Baldwin III, W. M., Claas, F. H. J., van Es, L. A. & van Rood, J. J. Transplantn Proc. 13, 103–107 (1981).
Google Scholar - Lampert, I. A., Suitters, A. J. & Chisholm, P. M. Nature 293, 149–150 (1981).
Article ADS CAS Google Scholar - Mason, D. W., Dallman, M. & Barclay, A. N. Nature 293, 150–151.
- Suitters, A. J. & Lampert, I. A. Br. J. exp. Path. 63, 207–213 (1982).
CAS Google Scholar - Hunter, W. M. & Greenwood, P. C. Nature 194, 459–460 (1962).
Article Google Scholar - Hoyer, L. W., De Los Santos, R. P. & Hoyer, J. R. J. clin. Invest. 52, 2737–2744 (1973).
Article CAS Google Scholar - Bowman, P. D. et al. In Vitro 17, 353–362 (1981).
Article CAS Google Scholar - Ozato, K., Mayer, N. & Sachs, D. H. J. Immun. 124, 533–540 (1980).
CAS PubMed Google Scholar - Lems, S. P. M. & Koene, R. A. P. ICRS med. Sci. 7, 184 (1979).
CAS Google Scholar - Beller, D. I. & Ho, K. J. Immun. 129, 123–131 (1982).
Google Scholar - Steeg, P. S., Moore, R. N. & Oppenheim, J. J. J. exp. Med. 152, 1734–1744 (1980).
Article CAS Google Scholar - Steinman, R. N., Nogueira, N., Witmer, M. D., Tydings, J. & Mellman, I. S. J. exp. Med. 152, 1248–1261 (1980).
Article CAS Google Scholar - Scher, M. G., Beller, D. I. & Unanue, E. R. J. exp. Med. 152, 1684–1698 (1980).
Article CAS Google Scholar - Steeg, P. S., Johnson, H. M. & Oppenheim, J. J. J. Immun. 129, 2402–2406 (1982).
CAS PubMed Google Scholar - Dvorak, H. F. et al. J. exp. Med. 150, 322–337 (1979).
Article CAS Google Scholar - Woodward, J. G., Shigekawa, B. L. & Frelinger, J. A. Transplantation 33, 254–259 (1982).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Department of Pathology and Department of Medicine, Division of Nephrology, Sint Radboudziekenhuis, University of Nijmegen, Nijmegen, The Netherlands
R. M. W. de Waal, M. J. J. Bogman, C. N. Maass, L. M. H. Cornelissen, W. J. M. Tax & R. A. P. Koene
Authors
- R. M. W. de Waal
You can also search for this author inPubMed Google Scholar - M. J. J. Bogman
You can also search for this author inPubMed Google Scholar - C. N. Maass
You can also search for this author inPubMed Google Scholar - L. M. H. Cornelissen
You can also search for this author inPubMed Google Scholar - W. J. M. Tax
You can also search for this author inPubMed Google Scholar - R. A. P. Koene
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
de Waal, R., Bogman, M., Maass, C. et al. Variable expression of Ia antigens on the vascular endothelium of mouse skin allografts.Nature 303, 426–429 (1983). https://doi.org/10.1038/303426a0
- Received: 13 January 1983
- Accepted: 10 March 1983
- Issue Date: 02 June 1983
- DOI: https://doi.org/10.1038/303426a0