Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells (original) (raw)

Nature volume 303, pages 429–431 (1983) Cite this article

Abstract

An important feature of Plasmodium falciparum malaria which differentiates it from other human malarias is that erythrocytes infected with trophozoites and schizonts are not present in the peripheral blood but are sequestered along capillary and venular endothelium1. Infected erythrocytes attach via parasite-induced ultrastructural modifications on the surface of the infected cells, called ‘knobs’2,3. This sequestration may be important for parasite survival because it prevents infected erythrocytes from circulating through the spleen where they could be eliminated. We have established an in vitro correlate of sequestration and used it to demonstrate that immune sera from repeatedly infected Aotus monkeys inhibit binding of infected erythrocytes to endothelial cells4. We have investigated whether antiserum that blocks binding of one isolate of P. falciparum to target cells can block or reverse binding of other isolates. We report here that sera which block or reverse binding are strain-specific, indicating that the corresponding antigens on the surface of the infected erythrocytes are strain (isolate)-specific.

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Authors and Affiliations

  1. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20205, USA
    Iroka J. Udeinya & Louis H. Miller
  2. Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    I. A. McGregor
  3. Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan, 48824, USA
    James B. Jensen

Authors

  1. Iroka J. Udeinya
  2. Louis H. Miller
  3. I. A. McGregor
  4. James B. Jensen

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Udeinya, I., Miller, L., McGregor, I. et al. Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells.Nature 303, 429–431 (1983). https://doi.org/10.1038/303429a0

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