A new H–2-linked class I gene whose expression depends on a maternally inherited factor (original) (raw)

Nature volume 306, pages 383–385 (1983)Cite this article

Abstract

The maternally transmitted antigen (Mta) is expressed on the cells of most strains of mice1,2. It is a medial histocompatibility antigen3, that is, it is recognized by unrestricted cytotoxic T lymphocytes as are major H antigens, but unlike these it is a weak transplantation antigen and does not itself restrict the T-cell recognition of minor H antigens. All other medial H antigens are encoded by genes closely linked to the major histocompatibility complex3, H–2 in the mouse. By contrast, Mta appeared to follow extrachromosomal, maternal inheritance. Several substrains of NZB, NZO and non-inbred European NMRI mice are Mta-negative. Females of these strains bear only Mta− offspring, while females of the inbred Mta+ strains bear only Mta+ offspring. Repeated backcrossing from Mta+ females to NZB or NMRI males has shown that, given the right cytoplasmic genes, the chromosomal genes of these Mta− strains permit expression of Mta2. As the Mta type of a mouse cannot be influenced by embryo transfer or foster nursing2,4, we concluded that it was determined by a cytoplasmic factor (Mtf), transmitted through the egg. We now show that a gene, Hmt, closely linked to the H–2 complex, is also required for expression of Mta.

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Authors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, Basel, CH-4005, Switzerland
    Kirsten Fischer Lindahl & Barbara Hausmann
  2. Department of Molecular Biology, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York, 14263, USA
    Verne M. Chapman

Authors

  1. Kirsten Fischer Lindahl
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  2. Barbara Hausmann
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  3. Verne M. Chapman
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Lindahl, K., Hausmann, B. & Chapman, V. A new _H–2_-linked class I gene whose expression depends on a maternally inherited factor.Nature 306, 383–385 (1983). https://doi.org/10.1038/306383a0

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