A putative second cell-derived oncogene of the avian leukaemia retrovirus E26 (original) (raw)

Nature volume 306, pages 395–397 (1983)Cite this article

Abstract

The acute avian leukaemia retroviruses AMV and E26 both induce myeloblastosis in vivo and transform myeloblasts _in vitro_1–5. Both viruses contain the oncogene v-myb first described for AMV6,7. Unlike AMV, E26 has the additional capacity to induce erythroblastosis in vivo and to transform erythroblasts4,5. Previous analyses indicated that the genome of E26 also contained nucleotide sequences distinct from v-myb and unrelated to viral replicative genes6,8,9. Using a molecularly cloned E26 provirus, we have now identified a novel nucleotide sequence designated v-ets (for _E_-twenty-six specific)10 of ∼1.5 kilobase pairs (kbp) located next to v-myb. v-ets possesses all the structural characteristics of a putative new oncogene: it has a conserved cellular counterpart c-ets which is transcribed in some normal chicken cells as a major 7.5-kb polyadenylated RNA. Although our results now await elucidation of their biological significance, we propose that v-ets could be a new oncogene accounting for the additional transforming properties of E26, or potentiating the transforming properties of the v-myb oncogene.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Graf, T. & Stehelin, D. Biochim. biophys. Acta 651, 245–271 (1982).
    CAS PubMed Google Scholar
  2. Beard, J. W. Adv. Cancer Res. 7, 1–127 (1963).
    Article CAS PubMed Google Scholar
  3. Ivanov, X., Mladenov, Z., Nedyalkov, S. & Todorov, T. G. Bull. Inst. Path. comp. Anim. Domest. 9, 5–36 (1962).
    Google Scholar
  4. Radke, K., Beug, H., Kornfeld, S. & Graf, T. Cell 31, 643–653 (1982).
    Article CAS PubMed Google Scholar
  5. Moscovici, M. G. et al. Virology 129, 65–78 (1983).
    Article CAS PubMed Google Scholar
  6. Roussel, M. et al. Nature 281, 452–455 (1979).
    Article ADS CAS PubMed Google Scholar
  7. Souza, L. M., Strommer, J. N., Hilyard, R. L., Komaromy, M. C. & Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 77, 5177–5181 (1980).
    Article ADS CAS Google Scholar
  8. Bister, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 3677–3681 (1982).
    Article ADS CAS Google Scholar
  9. Stehelin, D. et al. Cold Spring Harb. Symp. quant. Biol. 44, 1215–1223 (1980).
    Article CAS PubMed Google Scholar
  10. Coffin, J. M. et al. J. Virol. 40, 953–957 (1981).
    CAS PubMed PubMed Central Google Scholar
  11. Gonda, T. J. et al. Cell 23, 279–290 (1981).
    Article CAS PubMed Google Scholar
  12. Saule, S. et al. J. Virol. 42, 71–82 (1982).
    CAS PubMed PubMed Central Google Scholar
  13. Delorbe, W. J., Luciw, P. A., Goodman, H. M., Varmus, H. E. & Bishop, J. M. J. Virol. 36, 50–61 (1980).
    CAS PubMed PubMed Central Google Scholar
  14. Gonda, T. J. & Bishop, J. M. J. Virol. 46, 212–220 (1983).
    CAS PubMed PubMed Central Google Scholar
  15. Leprince, D. et al. EMBOJ J. 2, 1073–1078 (1983).
    Article CAS Google Scholar
  16. Vennstrom, B. & Bishop, J. M. Cell 28, 135–143 (1982).
    Article CAS PubMed Google Scholar
  17. Sheiness, D., Hughes, S. H., Varmus, H. E., Stubblefield, E. & Bishop, J. M. Virology 105, 415–424 (1980).
    Article CAS PubMed Google Scholar
  18. Wang, J. Y. J. & Baltimore, D. Molec. cell. Biol. 3, 773–779 (1983).
    Article CAS PubMed PubMed Central Google Scholar
  19. Ellis, R. W. et al. Nature 292, 506–511 (1981).
    Article ADS CAS PubMed Google Scholar
  20. Rushlow, K. E. et al. Science 216, 1421–1423 (1982).
    Article ADS CAS PubMed Google Scholar
  21. Klempnauer, K. H., Gonda, T. J. & Bishop, J. M. Cell 31, 453–463 (1982).
    Article CAS PubMed Google Scholar
  22. Nazerian, K. & Sharma, J. M. J. natn. Cancer Inst. 54, 277–279 (1979).
    Article Google Scholar
  23. Gonda, T. J., Sheiness, D. K. & Bishop, J. M. Molec. cell. Biol. 2, 617–624 (1982).
    Article CAS PubMed PubMed Central Google Scholar
  24. Beug, H., Hayman, M. J. & Graf, T. EMBO J. 1, 1069–1073 (1982).
    Article CAS PubMed PubMed Central Google Scholar
  25. Boyle, W. J., Lipsick, J. S., Reddy, P. E. & Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 80, 2834–2838 (1983).
    Article ADS CAS Google Scholar
  26. Coll, J. et al. EMBO J. 2 (in the press).
  27. Hayman, M. J. et al. Cell 32, 579–588 (1983).
    Article CAS PubMed Google Scholar
  28. Frykberg, L. et al. Cell 32, 227–238 (1983).
    Article CAS PubMed Google Scholar
  29. Land, H., Parada, L. F. & Weinberg, R. A. Nature 304, 596–602 (1983).
    Article ADS CAS PubMed Google Scholar
  30. Ruley, H. E. Nature 304, 602–606 (1983).
    Article ADS CAS PubMed Google Scholar
  31. Newbold, R. F. & Overell, R. W. Nature 304, 648–651 (1983).
    Article ADS CAS PubMed Google Scholar

Download references

Author information

Authors and Affiliations

  1. Laboratoire d'Oncologire Moleculaire, INSERM Unité 186, Institut Pasteur, 15 Rue C. Guerin, Lille Cedex, 59019, France
    D. Leprince, A. Gegonne, J. Coll, C. de Taisne, A. Schneeberger, C. Lagrou & D. Stehelin

Authors

  1. D. Leprince
  2. A. Gegonne
  3. J. Coll
  4. C. de Taisne
  5. A. Schneeberger
  6. C. Lagrou
  7. D. Stehelin

Rights and permissions

About this article

Cite this article

Leprince, D., Gegonne, A., Coll, J. et al. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.Nature 306, 395–397 (1983). https://doi.org/10.1038/306395a0

Download citation

This article is cited by