Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity (original) (raw)

Nature volume 309, pages 276–279 (1984)Cite this article

Abstract

Human T-cell leukaemias and lymphomas associated with the human T-cell leukaemia viruses (HTLV)1–3are invariably neoplasms of cells with mature T-lymphocyte phenotype4,5. Epstein–Barr virus-transformed B-lymphocyte lines which are productively infected with HTLV may be isolated from patients with HTLV malignancies6,7, but no non-lymphoid tissues seem to be involved. Here, to investigate the basis for this tissue specificity, we introduced type II HTLV (HTLV-II) into a variety of human cells by infection and also by transfection of recombinant genomes. We found no HTLV-II expression in non-lymphoid tissues although expression and correct initiation of transcription was observed in B and T lymphocytes. Our results using recombinant genomes indicate that the restriction of expression is at least partly due to _cis_-acting functions of the long terminal repeats which lie at each end of the HTLV genome.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, 90024, USA
    Irvin S. Y. Chen, Jami McLaughlin & David W. Golde

Authors

  1. Irvin S. Y. Chen
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  2. Jami McLaughlin
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  3. David W. Golde
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Chen, I., McLaughlin, J. & Golde, D. Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity.Nature 309, 276–279 (1984). https://doi.org/10.1038/309276a0

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