Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity (original) (raw)
- Letter
- Published: 17 May 1984
Nature volume 309, pages 276–279 (1984)Cite this article
- 45 Accesses
- 83 Citations
- 3 Altmetric
- Metrics details
Abstract
Human T-cell leukaemias and lymphomas associated with the human T-cell leukaemia viruses (HTLV)1–3are invariably neoplasms of cells with mature T-lymphocyte phenotype4,5. Epstein–Barr virus-transformed B-lymphocyte lines which are productively infected with HTLV may be isolated from patients with HTLV malignancies6,7, but no non-lymphoid tissues seem to be involved. Here, to investigate the basis for this tissue specificity, we introduced type II HTLV (HTLV-II) into a variety of human cells by infection and also by transfection of recombinant genomes. We found no HTLV-II expression in non-lymphoid tissues although expression and correct initiation of transcription was observed in B and T lymphocytes. Our results using recombinant genomes indicate that the restriction of expression is at least partly due to _cis_-acting functions of the long terminal repeats which lie at each end of the HTLV genome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Poiesz, B. J. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7415–7419 (1980).
Article ADS CAS Google Scholar - Hinuma, Y. et al. Proc. natn. Acad. Sci. U.S.A. 78, 6476–6480 (1981).
Article ADS CAS Google Scholar - Kalyanaraman, V. S. et al. Science 218, 571–573 (1982).
Article ADS CAS Google Scholar - Gallo, R. C. et al. Cancer Res. 43, 3892–3899 (1983).
CAS PubMed Google Scholar - Saxon, A., Stevens, R. H. & Golde, D. W. Ann. intern. Med. 88, 323–326 (1978).
Article CAS Google Scholar - Yamamoto, N., Matsumoto, T., Koyanagi, Y., Tanaka, Y. & Hinuma, Y. Nature 299, 367–369 (1982).
Article ADS CAS Google Scholar - Chen, I. S. Y., Quan, S. G. & Golde, D. W. Proc. natn. Acad. Sci. U.S.A. 80, 7006–7009 (1983).
Article ADS CAS Google Scholar - Glaser, R. & Nonoyama, M. J. Virol. 14, 174–176 (1974).
CAS PubMed PubMed Central Google Scholar - Glaser, R. & Rapp, F. J. Virol. 10, 288–296 (1972).
CAS PubMed PubMed Central Google Scholar - Southern, E. M. & Berg, P. J. molec. appl. Genet. 1, 327–341 (1982).
CAS Google Scholar - Bacchetti, S. & Graham, F. L. Proc. natn. Acad. Sci. U.S.A. 74, 590–594 (1977).
Article Google Scholar - Wigler, M. et al. Cell 16, 777–785 (1979).
Article CAS Google Scholar - Chen, I. S. Y., McLaughlin, J., Gasson, J.C., Clark, S.C. & Golde, D.W. Nature 305, 502–505 (1983).
Article ADS CAS Google Scholar - Temin, H. M. Cell 27, 1–3 (1981).
Article CAS Google Scholar - Temin, H. M. Cell 28, 3–5 (1982).
Article CAS Google Scholar - Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983).
Article CAS Google Scholar - Chandler, V. L., Maler, B. A. & Yamamoto, K. R. Cell 33, 489–499 (1983).
Article CAS Google Scholar - Southern, E.M. J. molec. Biol. 98, 503–517 (1975).
Article CAS Google Scholar - Rhim, J. S., Cho, H. Y. & Huebner, R. J. Int. J. Cancer 15, 23–29 (1975).
Article CAS Google Scholar - Shimotohno, K., Golde, D. W., Miwa, M., Sugimura, T. & Chen, I. S. Y. Proc. natn. Acad. Sci. U S. A. 81, 1079–1083 (1984).
Article ADS CAS Google Scholar - Seiki, M., Hattori, S., Hirayama, Y. & Yoshida, M. Proc. natn. Acad. Sci. U.S.A. 80, 3618–3622 (1983).
Article ADS CAS Google Scholar - Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).
Article CAS Google Scholar - Queen, G. & Baltimore, D. Cell 33, 741–748 (1983).
Article CAS Google Scholar - Thomas, P. S. Proc. natn. Acad. Sci. U.S.A. 77, 5201–5205 (1980).
Article ADS CAS Google Scholar - Berk, A. J. & Sharp, P. A. Cell 12, 721–732 (1977).
Article CAS Google Scholar - Schaffner, W. Proc. natn. Acad. Sci. U.S.A. 77, 2163–2167 (1980).
Article ADS CAS Google Scholar
Author information
Authors and Affiliations
- Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, 90024, USA
Irvin S. Y. Chen, Jami McLaughlin & David W. Golde
Authors
- Irvin S. Y. Chen
You can also search for this author inPubMed Google Scholar - Jami McLaughlin
You can also search for this author inPubMed Google Scholar - David W. Golde
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Chen, I., McLaughlin, J. & Golde, D. Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity.Nature 309, 276–279 (1984). https://doi.org/10.1038/309276a0
- Received: 17 November 1983
- Accepted: 13 March 1984
- Issue Date: 17 May 1984
- DOI: https://doi.org/10.1038/309276a0