Help for cytotoxic-T-cell responses is mediated by CD40 signalling (original) (raw)

References

  1. Keene, J. A. & Forman, J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155, 768–782 (1982).
    Article CAS Google Scholar
  2. von Herrath, M. G., Yokoyama, M., Dockter, J., Oldstone, M. B. & Whitton, J. L. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance ot subsequent virus challenge. J. Virol. 70, 1072–1079 (1996).
    CAS PubMed PubMed Central Google Scholar
  3. Cardin, R. D., Brooks, J. W., Sarawar, S. R. & Doherty, P. C. Progressive loss of CD8+ T cell-mediated control of a γ-herpesvirus in the absence of CD4+ T cells. J. Exp. Med. 184, 863–871 (1996).
    Article CAS Google Scholar
  4. Bennett, S. R., Carbone, F. R., Karamalis, F., Miller, J. F. A. P. & Heath, W. R. Induction of a CD8 cytotoxic T lymphocyte response by cross-priming requires cognate CD4 help. J. Exp. Med. 186, 65–70 (1997).
    Article CAS Google Scholar
  5. Guerder, S. & Matzinger, P. Afail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176, 553–564 (1992).
    Article CAS Google Scholar
  6. Butler, R. M., Holmes, K. L., Hugin, A., Frederickson, T. N. & Morse, H. C. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells. Nature 328, 77–79 (1987).
    Article ADS Google Scholar
  7. Ahmed, R., Butler, L. D. & Bhatti, L. T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody respones. J. Virol. 62, 2102–2106 (1988).
    CAS PubMed PubMed Central Google Scholar
  8. Ke, Y. & Kapp, J. A. Oral antigen inhibits priming of D8+CTL, CD4+ T cells, and antibody responses while activating D8+ suppressor T cells. J. Immunol. 156, 916–921 (1996).
    CAS PubMed Google Scholar
  9. Carbone, F. R. & Bevan, M. J. Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J. Exp. Med. 171, 377–387 (1990).
    Article CAS Google Scholar
  10. Stout, R. D. & Suttles, J. The many roles of CD40 in cell-mediated inflammatory responses. Immunol. Today 17, 487–492 (1996).
    Article CAS Google Scholar
  11. Grewal, I. S. & Flavell, R. A. Acentral role of CD40 ligand in the regulation of CD4+ T-cell responses. Immunol. Today 17, 410–414 (1996).
    Article CAS Google Scholar
  12. Yang, Y. et al. Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J. Virol. 70, 6370–6377 (1996).
    CAS PubMed PubMed Central Google Scholar
  13. Borrow, P. et al. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J. Exp. Med. 183, 2129–2142 (1996).
    Article CAS Google Scholar
  14. Yang, Y. & Wilson, J. M. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 273, 1862–1864 (1996).
    Article ADS CAS Google Scholar
  15. Roy, M., Waldschmidt, T., Aruffo, A., Ledbetter, J. A. & Noelle, R. J. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J. Immunol. 151, 2497–2510 (1993).
    CAS PubMed Google Scholar
  16. Sad, S. et al. Cytotoxicity and weak CD40 ligand expression of D8+ type 2 cytotoxic T cells restricts their potential B cell helper activity. Eur. J. Immunol. 27, 914–922 (1997).
    Article CAS Google Scholar
  17. Rolink, A., Melchers, F. & Andersson, J. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5, 319–330 (1996).
    Article CAS Google Scholar
  18. Sallusto, F., Cella, M., Danieli, C. & Lanzavecchia, A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389–400 (1995).
    Article CAS Google Scholar
  19. Grewal, I. S. et al. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 273, 1864–1867 (1996).
    Article ADS CAS Google Scholar
  20. Guo, Y. et al. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J. Exp. Med. 184, 955–961 (1996).
    Article CAS Google Scholar
  21. Shinde, S. et al. CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L. J. Immunol. 157, 2764–2768 (1996).
    CAS PubMed Google Scholar
  22. Alderson, M. R. et al. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 178, 669–674 (1993).
    Article CAS Google Scholar
  23. Wagner, D. J., Stout, R. D. & Suttles, J. Role of the CD40-CD40 ligant interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur. J. Immunol. 24, 3148–3154 (1994).
    Article CAS Google Scholar
  24. Shu, U. et al. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25, 1125–1128 (1995).
    Article CAS Google Scholar
  25. Kiener, P. A. et al. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155, 4917–4925 (1995).
    CAS Google Scholar
  26. Fuchs, E. J. & Matzinger, P. Bcells turn off virgin but not memory T cells. Science 258, 1156–1159 (1992).
    Article ADS CAS Google Scholar
  27. Armitage, R. J. et al. CD40 ligand is a T cell growth factor. Eur. J. Immunol. 23, 2326–2321 (1993).
    Article CAS Google Scholar
  28. Whitmire, J. K., Slifka, M. K., Grewal, I. S., Flavell, R. A. & Ahmed, R. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection. J. Virol. 70, 8375–8381 (1996).
    CAS PubMed PubMed Central Google Scholar
  29. Xu, J. et al. Mice deficient for the D40 ligand. Immunity 1, 423–431 (1994).
    Article CAS Google Scholar
  30. Kawabe, T. et al. The immune responses in D40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1, 167–178 (1994).
    Article CAS Google Scholar

Download references