- Simpson, E. & Gordon, R. D. Responsiveness to H-Y antigen. Ir-gene complementation and target cell specificity. Immunol. Rev. 35, 59–75 (1997).
Article Google Scholar
- Husmann, L. A. & Bevan, M. J. Cooperation between helper T cells and cytotoxic T lymphocyte precursors. Ann. NY Acad. Sci. 532, 158–169 (1988).
Article ADS CAS Google Scholar
- Bennett, S. R. M., Carbone, F. R., Karamalis, F., Miller, J. F. A. P. & Heath, W. R. Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J. Exp. Med. 186, 65–70 (1997).
Article CAS Google Scholar
- Keene, J. & Forman, J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155, 768–782 (1982).
Article CAS Google Scholar
- Guerder, S. & Matzinger, P. Afail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176, 553–564 (1992).
Article CAS Google Scholar
- Grewal, I. S., Xu, J. & Flavell, R. A. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378, 617–620 (1995).
Article ADS CAS Google Scholar
- van Essen, D., Kikutani, H. & Gray, D. CD40 ligand-transduced co-stimulation of T cells in the development of helper function. Nature 378, 620–623 (1995).
Article ADS CAS Google Scholar
- Koch, F. et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184, 741–746 (1996).
Article CAS Google Scholar
- Cella, M. et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184, 747–752 (1996).
Article CAS Google Scholar
- Stout, R. D., Suttles, J., Xu, J.-C., Grewal, I. S. & Flavell, R. A. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J. Immunol. 156, 8–11 (1996).
CAS PubMed Google Scholar
- Kennedy, M. K. et al. Induction of B cell costimulatory function by recombinant murine CD40 ligand. Eur. J. Immunol. 24, 116–123 (1994).
Article CAS Google Scholar
- Toes, R. E. M. et al. Protective anti-tumor immunity induced by immunization with completely allogeneic tumor cells. Cancer Res. 56, 3782–3787 (1996).
CAS PubMed Google Scholar
- Bevan, M. J. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic asay. J. Exp. Med. 143, 1283–1288 (1976).
Article CAS Google Scholar
- Huang, A. Y. et al. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264, 961–965 (1994).
Article ADS CAS Google Scholar
- Grewal, I. S. & Flavell, R. A. Acentral role of CD40 ligand in the regulation of CD4+ T-cell responses. Immunol. Today 17, 410–414 (1996).
Article CAS Google Scholar
- Noelle, R. CD40 and its ligand in host defense. Immunity 4, 415–419 (1996).
Article CAS Google Scholar
- Soong, L. et al. Disruption of CD40–CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4, 263–273 (1996).
Article CAS Google Scholar
- Mackey, M. F. et al. Protective immunity induced by tumor vaccines requires interactions between CD40 and its ligand, CD154. Cancer Res. 57, 2569–2574 (1997).
CAS PubMed Google Scholar
- Rolink, A., Melchers, F. & Andersson, J. The SCID but not the RAG-2 gene product is required for the S mu-S epsilon heavy chain class switching. Immunity 5, 319–330 (1996).
Article CAS Google Scholar
- Grusby, M. J., Johnson, R. S., Papaioannou, V. E. & Glimcher, L. H. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 253, 1417–1420 (1991).
Article ADS CAS Google Scholar
- Shinde, S. et al. CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly upregulated by CD40L. J. Immunol. 157, 2764–2768 (1996).
CAS PubMed Google Scholar
- Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. AB cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350, 423–426 (1991).
Article ADS CAS Google Scholar
- Noelle, R. J. et al. A39-kDa protein on activated T helper cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl Acad. Sci. USA 89, 6550–6554 (1992).
Article ADS CAS Google Scholar
- Yang, Y. & Wilson, J. M. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 273, 1862–1864 (1996).
Article ADS CAS Google Scholar
- Steinman, R. M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271–296 (1991).
Article CAS Google Scholar
- Mayordomo, J. I. et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nature Med. 1, 1297–1302 (1995).
Article CAS Google Scholar
- Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. A. P. & Heath, W. R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med. 186, 239–245 (1997).
Article CAS Google Scholar
- Kast, W. M. et al. Eradication of adenovirus E1-induced tumors by E1a-specific cytotoxic T lymphocytes. Cell 59, 603–614 (1989).
Article CAS Google Scholar
- Dialynas, D. P. et al. Characterization of the murine T cell surface molecule, designated L3T4, identified by the monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131, 2445–2451 (1983).
CAS PubMed Google Scholar