Induction of c-fos during myelomonocytic differentiation and macrophage proliferation (original) (raw)

Nature volume 314, pages 546–548 (1985)Cite this article

Abstract

Previous studies have suggested a role for c-fos in cellular differentiation in fetal membranes_1–3_, haematopoietic cells4,5 and teratocarcinoma stem cells6. In other cell types, such as fibroblasts, c-fos expression is normally very low, but is rapidly induced by peptide growth factors, implicating c-fos in growth control mechanisms7–10. Here, we show that the TPA (12-_O_-tetradecanoylphorbol-13-acetate)-induced macrophage-like differentiation of HL60 human promyelocytic precursor cells11,12 is accompanied by the induction of both c-fos mRNA and protein within 15 min after treatment, suggesting a functional role for c-fos in this differentiation system. In quiescent terminally differentiated macrophages, expression of c-fos is inducible by the macrophage-specific growth factor colony-stimulating factor-1 (CSF-1)13. The kinetics of c-fos induction, however, are entirely different from those in growth factor-stimulated fibroblasts, supporting the view that the c-fos gene product may serve different functions in different cell types.

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Author notes

  1. Tom Curran: Department of Molecular Genetics, Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA.

Authors and Affiliations

  1. European Molecular Biology Laboratory, Postfach 10.2209, 6900, Heidelberg, FRG
    Rolf Müller, Tom Curran, Dagmar Müller & Larry Guilbert

Authors

  1. Rolf Müller
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  2. Tom Curran
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  3. Dagmar Müller
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  4. Larry Guilbert
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Müller, R., Curran, T., Müller, D. et al. Induction of c-fos during myelomonocytic differentiation and macrophage proliferation.Nature 314, 546–548 (1985). https://doi.org/10.1038/314546a0

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