Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators (original) (raw)

References

  1. Schoonjans, K., Martin, G., Staels, B. & Auwerx, J. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr. Opin. Lipidol. 8, 159–166 (1997).
    Article CAS Google Scholar
  2. Devchand, P. R. et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 384, 39–43 (1996).
    Article ADS CAS Google Scholar
  3. Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801–809 (1993).
    Article ADS CAS Google Scholar
  4. Saitoh, K. et al. Anti-atheromatous effects of fenofibrate, a hypolipidemic drug. I: Anti-atheromatous effects are independent of its hypolipidemic effect in cholesterol-fed rabbits. Folia Pharmacol. Japon. 106, 41–50 (1995).
    Article CAS Google Scholar
  5. Ericsson, C. G. et al. Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. Lancet 347, 849–853 (1996).
    Article CAS Google Scholar
  6. Auboeuf, D. et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans. No alterations in adipose tissue of obese and NIDDM patients. Diabetes 46, 1319–1327 (1997).
    Article CAS Google Scholar
  7. Loppnow, H. & Libby, P. Proliferating or interleukin-1 activated human vascular smooth muscle cells secrete copious interleukin 6. J. Clin. Invest. 85, 731–738 (1990).
    Article CAS Google Scholar
  8. Forman, B. M., Chen, J. & Evans, R. M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl Acad. Sci. USA 94, 4312–4317 (1997).
    Article ADS CAS Google Scholar
  9. Vu-Dac, N. et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J. Clin. Invest. 96, 741–750 (1995).
    Article CAS Google Scholar
  10. Balfour, J. A., McTavish, D. & Heel, R. C. Fenofibrate, a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia. Drugs 40, 260–290 (1990).
    Article CAS Google Scholar
  11. Todd, P. A. & Ward, A. Gemfibrozil, a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia. Drugs 36, 314–339 (1988).
    Article CAS Google Scholar
  12. Lehmann, J. M. et al. An antidiabetic thiazolidinedione is a high affinity ligand for Peroxisome Proliferator-Activated Receptor γ (PPARγ). J. Biol. Chem. 270, 12953–12956 (1995).
    Article CAS Google Scholar
  13. Newton, R., Kuitert, L. M. E., Bergmann, M., Adcock, I. M. & Barnes, P. J. Evidence for involvement of NF-κB in the transcriptional control of COX-2 gene expression by IL-1β. Biochem. Biophys. Res. Commun. 237, 28–32 (1997).
    Article CAS Google Scholar
  14. Kutchera, W. et al. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. Proc. Natl Acad. Sci. USA 93, 4816–4820 (1996).
    Article ADS CAS Google Scholar
  15. Xie, W. & Herschman, H. R. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum. J. Biol. Chem. 271, 31742–31748 (1996).
    Article CAS Google Scholar
  16. Yamamoto, K., Arakawa, T., Ueda, N. & Yamamoto, S. Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270, 31315–31320 (1995).
    Article CAS Google Scholar
  17. Liuzzo, G. et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N. Engl. J. Med. 331, 417–424 (1994).
    Article CAS Google Scholar
  18. Thompson, S. G., Kienast, J., Pyke, S. D. M., Haverkate, F. & van de Loo, J. C. W. Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. N. Engl. J. Med. 332, 635–641 (1995).
    Article CAS Google Scholar
  19. Ricote, M., Li, A. C., Willsson, T. M., Kelly, C. J. & Glass, C. K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79–82 (1998).
    Article ADS CAS Google Scholar
  20. Jiang, C., Ting, A. T. & Seed, B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82–86 (1998).
    Article ADS CAS Google Scholar
  21. Galis, Z. S., Sukhova, G. K., Lark, M. W. & Libby, P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J. Clin. Invest. 94, 2493–2503 (1994).
    Article CAS Google Scholar
  22. Brand, K. et al. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J. Clin. Invest. 97, 1715–1722 (1996).
    Article CAS Google Scholar
  23. Bourcier, T., Sukhova, G. & Libby, P. The nuclear factor κ-B signalling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis. J. Biol. Chem. 272, 15817–15824 (1997).
    Article CAS Google Scholar
  24. Rich, B. E. & Steitz, J. A. Human acidic ribosomal phosphoprotein P0, P1 and P2: analysis of cDNA clones, in vitro synthesis and assembly. Mol. Cell. Biol. 7, 4065–4074 (1987).
    Article CAS Google Scholar
  25. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693–702 (1991).
    Article CAS Google Scholar
  26. Clauss, A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 17, 237–246 (1957).
    Article CAS Google Scholar
  27. Belmin, J. et al. Increased production of tumor necrosis factor and interleukin 6 by the arterial wall of aged rats. Am. J. Physiol. 268, H2288–H2293 (1995).
    ADS CAS PubMed Google Scholar
  28. Pradelles, P., Grassi, J. & Maclouf, J. Enzyme immunoassay of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Analyt. Chem. 57, 1170–1173 (1985).
    Article CAS Google Scholar
  29. Habib, A. et al. Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J. Biol. Chem. 268, 23448–23454 (1993).
    CAS PubMed Google Scholar
  30. Jones, D. A., Carlton, D. P., McIntyre, M. P., Zimmerman, G. A. & Prescott, S. M. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem. 268, 9049–9054 (1993).
    CAS PubMed Google Scholar

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