Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus (original) (raw)
- Letter
- Published: 20 March 1986
- Charles Van Beveren1 na1,
- Douglas Smith1,
- Ellson Chen1,
- Richard L. Mitchell1 na1,
- Clare M. Isacke1 na1,
- Inder M. Verma1 na1 &
- …
- Axel Ullrich1
Nature volume 320, pages 277–280 (1986)Cite this article
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Abstract
A role for proto-oncogenes in the regulation and modulation of cell proliferation1,2 has been suggested by the findings that the B-chain of platelet-derived growth factor (PDGF) is encoded by the proto-oncogene _sis_3–7 and that the erb-B oncogene product is a truncated form of the epidermal growth factor (EGF) receptor8–10. Furthermore, the product of the proto-oncogene fms (c-fms) may be related or identical to the receptor for macrophage colony-stimulating factor (CSF-1)11. v-fms is the transforming gene of the McDonough strain of feline sarcoma virus (SM-FeSV)12,13 and belongs to the family of _src_-related oncogenes which have tyrosine-specific kinase activity. Furthermore, nucleo-tide sequence analysis of the v-fms gene product revealed topologi-cal properties of a cell-surface receptor protein14. To elucidate the features involved in the conversion of a normal cell-surface receptor gene into an oncogenic one, we have now determined the complete nucleotide sequence of a human c-fms complementary DNA. The 972-amino-acid c-fms protein has an extracellular domain, a membrane-spanning region, and a cytoplasmic tyrosine protein kinase domain. Comparison of the feline v-fms and human c-fms sequences reveals that the proteins share extensive homology but have different carboxyl termini.
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Author notes
- Charles Van Beveren, Richard L. Mitchell, Clare M. Isacke and Inder M. Verma: Molecular Biology and Virology Laboratory, Salk Institute, PO Box 85800, San Diego, California 92138, USA
Authors and Affiliations
- Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA
Lisa Coussens, Charles Van Beveren, Douglas Smith, Ellson Chen, Richard L. Mitchell, Clare M. Isacke, Inder M. Verma & Axel Ullrich
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Coussens, L., Van Beveren, C., Smith, D. et al. Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus.Nature 320, 277–280 (1986). https://doi.org/10.1038/320277a0
- Received: 01 November 1985
- Accepted: 16 January 1986
- Issue Date: 20 March 1986
- DOI: https://doi.org/10.1038/320277a0