Synthesis of fast myosin induced by fast ectopic innervation of rat soleus muscle is restricted to the ectopic endplate region (original) (raw)
- Letter
- Published: 14 August 1986
Nature volume 322, pages 637–639 (1986)Cite this article
Abstract
Skeletal muscle fibres, long multinucleated cells, arise by fusion of mononucleated myoblasts to form a myotube that matures into the adult fibre. The two major types of mature fibre, fast and slow fibres, differ physiologically in their rate of isotonic shortening1. At the molecular level these type-specific physiological properties are ascribed to different isoforms of myosin, a major protein involved in shortening2,3. Differentiation of fast and slow fibres seems to be under the control of motoneurones4, and mature fibres are innervated by only one motoneurone. When rat soleus muscle (SOL, a slow muscle) is dually innervated with a fast nerve, it acquires some properties of a fast muscle, that is, low sensitivity to caffeine and high glycogen content5. We report here that in dually innervated soleus muscle the foreign fast nerve induces synthesis of fast isoforms of myosin, but only in the segment of the muscle fibre that is close to the foreign endplate. The localized influence of the nerve endplates suggest that factors controlling the phenotypic expression of the muscle fibre have a short range of activity.
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References
- Close, R. I. Physiol. Rev. 52, 129–197 (1972).
Article CAS Google Scholar - Barany, M. J. gen. Physiol. 50, 197–218 (1967).
Article Google Scholar - Dhoot, G. K. & Perry, S. V. Nature 278, 714–718 (1979).
Article ADS CAS Google Scholar - Buller, A. J., Eccles, J. C. & Eccles, R. M. J. Physiol., Lond. 150, 417–439 (1960).
Article CAS Google Scholar - Gutmann, E. & Hanzlikova, V. Physiol., Bohem. 16, 244–250 (1967).
CAS Google Scholar - Lomo, T. & Slater, C. R. J. Physiol., Lond. 275, 391–402 (1978).
Article CAS Google Scholar - Frank, E., Jansen, J. K. S., Lomo, T. & Westgaard, R. H. J. Physiol., Lond. 247, 725–743 (1975).
Article CAS Google Scholar - Salviati, G., Betto, R. & Danieli-Betto, D. Biochem. J. 207, 261–272 (1982).
Article CAS Google Scholar - Laemmli, U. K. Nature 227, 680–685 (1970).
Article ADS CAS Google Scholar - Salviati, G., Betto, R., Danieli-Betto, D. & Zeviani, M. Biochem. J. 224, 215–225 (1984).
Article CAS Google Scholar - Kuffler, D. P., Thompson, W. & Jansen, J. K. S. Proc. R. Soc. 208, 189–222 (1980).
ADS CAS Google Scholar - Frank, E., Gautvik, K. & Sommerschild, H. Acta Physiol., Scand. 95, 66–76 (1976).
Article Google Scholar - Carraro, U. & Catani, C. Biochem. biophys. Res. Commun. 116, 793–802 (1983).
Article CAS Google Scholar - Gauthier, G. F., Burke, R. E., Lowey, S. & Hobbs, A. W. J. Cell Biol. 97, 756–771 (1983).
Article CAS Google Scholar - Salmons, S. & Sreter, F. A. Nature 263, 30–34 (1976).
Article ADS CAS Google Scholar - Pette, D. & Schnez, U. FEES Lett. 83, 128–130 (1977).
Article CAS Google Scholar - Guth, L. Physiol. Rev. 48, 645–687 (1968).
Article CAS Google Scholar - Gutmann, E. A. Rev. Physiol. 38, 177–216 (1976).
Article CAS Google Scholar - McArdle, J. J. Prog. Neurobiol. 21, 135–198 (1983).
Article CAS Google Scholar - Lomo, T. & Westgaard, R. H. J. Physiol., Lond. 252, 603–626 (1975).
Article CAS Google Scholar - Pavlath, G. K. & Blau, H. M. J. Cell Biol. 102, 124–130 (1986).
Article CAS Google Scholar - Frair, P. M. & Peterson, A. C. Expl. Cell Res. 145, 167–178 (1983).
Article CAS Google Scholar - Towbin, H., Staehelin, T. & Gordon, J. Proc. natn. Acad. Sci. U.S.A. 76, 4350–4354 (1979).
Article ADS CAS Google Scholar - Szent-Gyorgyi, A. G. J. biol Chem. 192, 361–369 (1951).
CAS PubMed Google Scholar
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Authors and Affiliations
- Centre di Studio per la Biologia e Fisiopatologia Muscolare del CNR, via Loredan 16, 35131, Padova, Italy
G. Salviati - Istituto di Patologia Generale dell'Universita' di Padova, via Loredan 16, 35131, Padova, Italy
G. Salviati, E. Biasia & M. Aloisi
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- G. Salviati
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Salviati, G., Biasia, E. & Aloisi, M. Synthesis of fast myosin induced by fast ectopic innervation of rat soleus muscle is restricted to the ectopic endplate region.Nature 322, 637–639 (1986). https://doi.org/10.1038/322637a0
- Received: 10 February 1986
- Accepted: 22 May 1986
- Issue Date: 14 August 1986
- DOI: https://doi.org/10.1038/322637a0