Interaction of peptide antigens and class II major histocompatibility complex antigens (original) (raw)
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- Published: 20 November 1986
Nature volume 324, pages 260–262 (1986)Cite this article
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Abstract
T lymphocytes require a foreign antigen to be presented on a cell surface in association with a self-transplantation antigen before they can recognize it effectively. This phenomenon is known as major histocompatibility complex (MHC) restriction1. It is not clear how an incalculably large number of foreign proteins form unique complexes with a very limited number of MHC molecules. We studied the recognition properties of T cells specific for a peptide derived from bacteriophage A cl protein. Analogues of this peptide, as well as peptides derived from other unrelated antigens which can be presented in the context of the same MHC molecule, can competitively inhibit activation of these T cells by the cl peptide. Furthermore, these unrelated antigens can stimulate cl-specific T cells if certain specific amino-acid residues are replaced. Here we suggest a model in which all antigens give rise to peptides that can bind to the same site on the MHC molecule. T-cell recognition of this site (which is presumed to be polymorphic) with or without antigen bound can explain self-selection in the thymus and MHC restriction.
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References
- Schwartz, R. H. A. Rev. Immun. 3, 237–261 (1985).
Article CAS Google Scholar - Rock, K. L. & Benacerraf, B. J. exp. Med. 157, 1618–1634 (1983).
Article CAS Google Scholar - Werdelin, O. J. Immun. 129, 1883–1891 (1982).
CAS PubMed Google Scholar - Shimonkevitz, R., Colon, S., Kappler, J. W., Marrack, P. & Grey, H. M. J. Immun. 133, 2067–2074 (1984).
CAS Google Scholar - Babbitt, B. P., Allen, P. M., Matsueda, G., Haber, E. & Unanue, E. R. Nature 317, 359–360 (1985).
Article ADS CAS Google Scholar - Watts, T. H., Gaub, H. E. & McConnell, H. M. Nature 320, 179–181 (1986).
Article ADS CAS Google Scholar - Ashwell, S. D. & Schwartz, R. H. Nature 320, 176–179 (1986).
Article ADS CAS Google Scholar - Finnegan, A. et al. J. exp. Med. 164, 899–910 (1986).
Article Google Scholar - Watts, T. H., Gariepy, J., Schoolnick, G. K. & McConnell, H. M. Proc. natn. Acad. Sci. U.S.A. 82, 5480–5484 (1985).
Article ADS CAS Google Scholar - Guillet, J.-G. et al. Proc. nain. Acad. Sci. U.S.A. (submitted).
- Delisi, C. & Berzofsky, J. A. Proc. natn. Acad. Sci. U.S.A. 82, 7048–7052 (1985).
Article ADS CAS Google Scholar - Townsend, A. R. M. et al. Cell 44, 959–968 (1986).
Article CAS Google Scholar - Sauer, R. T. & Anderegg, R. Biochemistry 17, 1092–1100 (1978)
Article CAS Google Scholar - Merrifield, R. B. J. Am. ehem. Soc. 85, 2149–2154 (1963).
Article CAS Google Scholar
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Author notes
- John A. Smith: Departments of Molecular Biology and Pathology, Massachusetts General Hospital and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA
Authors and Affiliations
- Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA
Jean-Gerrard Guillet, Ming-Zong Lai, Thomas J. Briner, John A. Smith & Malcolm L. Gefter
Authors
- Jean-Gerrard Guillet
You can also search for this author inPubMed Google Scholar - Ming-Zong Lai
You can also search for this author inPubMed Google Scholar - Thomas J. Briner
You can also search for this author inPubMed Google Scholar - John A. Smith
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Guillet, JG., Lai, MZ., Briner, T. et al. Interaction of peptide antigens and class II major histocompatibility complex antigens.Nature 324, 260–262 (1986). https://doi.org/10.1038/324260a0
- Received: 02 July 1986
- Accepted: 11 September 1986
- Issue Date: 20 November 1986
- DOI: https://doi.org/10.1038/324260a0