AIDS virus-specific cytotoxic T lymphocytes in lung disorders (original) (raw)

Nature volume 328, pages 348–351 (1987)Cite this article

Abstract

Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome)1,2. HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in humans3,4 and apes5. We describe an experimental system permitting the quantitative and systematic analysis of HIV-specific cytotoxic T lymphocytes (CTL). Functional, HIV-specific CTL are obtained by broncho-alveolar lavage (BAL) from the lungs of seropositive patients with lymphocytic alveolitis6. These alveolar CTL: (1) recognize and kill HIV-infected alveolar macrophages in vitro under autologous, but not heterologous, conditions; (2) correspond to standard CTL as they express the CD3 and CDS surface markers, but not the CD4 marker; and (3) are restricted by class I HLA transplantation antigens in their cytotoxic activities. We propose the hypothesis that interactions between HIV-specific CTL and infected macrophages induce major inflammatory reactions in seropositive patients.

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Authors and Affiliations

  1. Laboratoire de Biologic et d'lmmunologie Moléculaires des Rétrovirus, Institut Pasteur, 75724, Paris, Cédex 15, France
    Fernando Plata, Livia Pedroza Martins & Simon Wain-Hobson
  2. Laboratoire d'lmmunologie Cellulaire et Tissulaire, Hôpital Pitié-Salpétrière, 75013, Paris, France
    Brigitte Autran, Martine Raphaël & Patrice Debré
  3. Service de Pneumologie, Hôpital Tenon, 75010, Paris, France
    Charles Mayaud, Michel Denis & Jean-Marc Guillon

Authors

  1. Fernando Plata
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  2. Brigitte Autran
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  3. Livia Pedroza Martins
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  4. Simon Wain-Hobson
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  5. Martine Raphaël
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  6. Charles Mayaud
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  7. Michel Denis
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  8. Jean-Marc Guillon
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  9. Patrice Debré
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Plata, F., Autran, B., Martins, L. et al. AIDS virus-specific cytotoxic T lymphocytes in lung disorders.Nature 328, 348–351 (1987). https://doi.org/10.1038/328348a0

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