Stabilization of wild-type p53 by hypoxia-inducible factor 1α (original) (raw)

References

  1. Graeber, T. G. et al. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14, 6264–6277 (1994).
    Article CAS PubMed PubMed Central Google Scholar
  2. Goldberg, M. A., Dunning, S. P. & Bunn, H. F. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242, 1412–1415 (1988).
    Article ADS CAS PubMed Google Scholar
  3. Salceda, S., Beck, I. & Caro, J. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activaiton by hypoxia. Arch. Biochem. Biophys. 384, 389–394 (1996).
    Article Google Scholar
  4. Gradin, K. et al. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol. Cell Biol. 16, 5221–5231 (1996).
    Article CAS PubMed PubMed Central Google Scholar
  5. Guillemin, K. & Krasnow, M. A. The hypoxic response: huffing and HIFing. Cell 89, 9–12 (1997).
    Article CAS PubMed Google Scholar
  6. Wang, G. L. & Semenza, G. L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implicaitons for model of hypoxia signal transduction. Blood 82, 3610–3615 (1993).
    CAS PubMed Google Scholar
  7. Wang, G. L. & Semenza, G. L. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268, 21513–21518 (1993).
    CAS PubMed Google Scholar
  8. Minchenko, A., Salceda, S., Bauer, T. & Caro, J. Hypoxia regulatory elements of the human vascular endothelial growth factor gene. Cell Mol. Biol. Res. 40, 35–39 (1994).
    CAS PubMed Google Scholar
  9. Levy, A. P., Levy, N. S., Wegner, S. & Goldberg, M. A. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 270, 13333–13340 (1995).
    Article CAS PubMed Google Scholar
  10. Hoffman, E. C. et al. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252, 954–958 (1991).
    Article ADS CAS PubMed Google Scholar
  11. Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A. & Simon, M. C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386, 403–407 (1997).
    Article ADS CAS PubMed Google Scholar
  12. Wang, G. L. & Semenza, G. L. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl Acad. Sci. USA 90, 4304–4308 (1993).
    Article ADS CAS PubMed PubMed Central Google Scholar
  13. Wang, G. L., Jiang, B.-H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2tension. Proc. Natl Acad. Sci. USA 92, 5510–5514 (1995).
    Article ADS CAS PubMed PubMed Central Google Scholar
  14. Wang, G. L. & Semenza, G. L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270, 1230–1237 (1995).
    Article CAS PubMed Google Scholar
  15. Wood, S. M., Gleadle, J. M., Pugh, C. W., Hankinson, O. & Ratcliffe, P. J. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. J. Biol. Chem. 271, 15117–15123 (1996).
    Article CAS PubMed Google Scholar
  16. Kallio, P. J., Pongratz, I., Gradin, K., McGuire, J. & Poellinger, L. Activaiton of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc. Natl Acad. Sci. USA 94, 5667–5672 (1997).
    Article ADS CAS PubMed PubMed Central Google Scholar
  17. Maki, C. G., Huibregtse, J. & Howley, P. M. In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res. 56, 2649–2654 (1996).
    CAS PubMed Google Scholar
  18. Whitesell, L. et al. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene 14, 2809–2816 (1997).
    Article CAS PubMed Google Scholar
  19. Andrews, N. & Faller, D. Arapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids. Res. 19, 2499 ((1991)).
    Article CAS PubMed PubMed Central Google Scholar
  20. Blagosklonny, M., Toretsky, J. & Neckers, L. Geldanamycin selectively destabilizes and conformationally alters mutated p53. Oncogene 11, 933–939 (1995).
    CAS PubMed Google Scholar
  21. Arany, Z. et al. An essential role for p300/CPB in the cellular response to hypoxia. Proc. Natl Acad. Sci. USA 93, 12969–12973 (1996).
    Article ADS CAS PubMed PubMed Central Google Scholar
  22. Huang, L. E., Arany, Z., Livingston, D. M. & Bunn, H. F. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. J. Biol. Chem. 271, 32253–32259 (1996).
    Article CAS PubMed Google Scholar
  23. El-Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817–825 (1993).
    Article CAS PubMed Google Scholar

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