Cerebellar complex spikes encode both destinations and errors in arm movements (original) (raw)

Nature volume 392, pages 494–497 (1998)Cite this article

Abstract

Purkinje cells of the cerebellum discharge complex spikes, named after the complexity of their waveforms1, with a frequency of ∼1 Hz during arm movements1,2,3,4,5,6,7,8,9,10,11,12,13. Despite the low frequency of firing, complex spikes have been proposed to contribute to the initiation of arm movements2,7,8,9,10 or to the gradual improvement of motor skills2,4,5,6,14,15,16. Here we recorded the activity of Purkinje cells fromthe hemisphere of cerebellar lobules IV–VI while trained monkeys made short-lasting reaching movements (of ∼200 milliseconds in duration) to touch a visual target that appeared at a random location on a tangent screen. We examined the relationship between complex-spike discharges and the absolute touch position, and between complex-spike discharges and relative errors in touching the screen. We used information theory to show that the complex spikes occurring at the beginning of the reach movement encode the absolute destination of the reach, and the complex spikes occurring at the end of the short-lasting movements encode the relative errors. Thus, complex spikes convey multiple types of information, consistent with the idea that they contribute both to the generation of movements and to the gradual, long-term improvement of these movements.

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Acknowledgements

We thank F. A. Miles and K. Kawano for comments on the manuscript; M. Okui for technical assistance; K. Kurata for useful advice; and S. Yamane and R. Suzuki for encouragement during this study.

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Authors and Affiliations

  1. Information Science Division, Electrotechnical Laboratory, Japan Science and Technology Corporation, Umezono, 1-1-4 305-8568, Tsukuba, Japan
    Shigeru Kitazawa & Tatsuya Kimura
  2. PRESTO, Japan Science and Technology Corporation, Umezono, 1-1-4 305-8568, Tsukuba, Japan
    Shigeru Kitazawa
  3. CREST, Japan Science and Technology Corporation, Umezono, 1-1-4 305-8568, Tsukuba, Japan
    Ping-Bo Yin

Authors

  1. Shigeru Kitazawa
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  2. Tatsuya Kimura
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  3. Ping-Bo Yin
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Correspondence toShigeru Kitazawa.

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Kitazawa, S., Kimura, T. & Yin, PB. Cerebellar complex spikes encode both destinations and errors in arm movements.Nature 392, 494–497 (1998). https://doi.org/10.1038/33141

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