A new natriuretic peptide in porcine brain (original) (raw)

Nature volume 332, pages 78–81 (1988)Cite this article

Abstract

Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure1–3. ANP-like immunoreactivity is also present in the brain, suggesting that the peptide functions as a neuro-peptide4,5. We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant activities. The complete amino-acid sequence determined for the peptide is remarkably similar to but definitely distinct from the known sequence of ANP1,3,6, indicating that the genes for the two are distinct. Thus, we have designated the peptide 'brain natriuretic peptide' (BNP). The occurrence of BNP with ANP in mammalian brain suggests the possibility that the physiological functions so far thought to be mediated by ANP may be regulated through a dual mechanism involving both ANP and BNP

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References

  1. Kangawa, K. & Matsuo, H. Biochem. biophys. Res. Commun. 118, 131–139 (1984).
    Article CAS Google Scholar
  2. de Bold, A. J. Science 230, 767–770 (1985).
    Article ADS CAS Google Scholar
  3. Matsuo, H. & Nakazato, H. Endocrinology Metabolism Clinics of North America, Vol. 16, Atrial Natriuretic Factor (eds Rosenblatt, M. & Jacobs, J. W.) 43–61 (Saunders, Philadelphia 1987).
    Google Scholar
  4. Samson, W. K. Endocrinology & Metabolism Clinics of North America, Vol. 16, Atrial Natriuretic Factor (eds Rosenblatt, M. & Jacobs, J. W.) 145–161 (Saunders, Philadelphia, 1987).
    Google Scholar
  5. Nakao, K. et al. J. Hypertension 4, (suppl. 6) 492–496 (1986).
    Google Scholar
  6. Forssmann, W. G. et al. Cell Tissue Res. 238, 425–430 (1984).
    Article CAS Google Scholar
  7. Currie, M. G. et al. Science 221, 71–73 (1983).
    Article ADS CAS Google Scholar
  8. Ueda, S. et al. Biochem. biophys. Res. Commun. 149, 1055–1062 (1987).
    Article CAS Google Scholar
  9. Oikawa, S. et al. Nature 309, 724–726 (1984).
    Article ADS CAS Google Scholar
  10. Oikawa, S. et al. Biochem. biophys. Res. Commun. 132, 892–899 (1985).
    Article CAS Google Scholar
  11. Kangawa, K., Fukuda, A. & Matsuo, H. Nature 313, 397–400 (1985).
    Article ADS CAS Google Scholar
  12. Miyata, A., Kangawa, K., Toshimori, T. & Matsuo, H. Biochem. biophys. Res. Commun. 129, 248–255 (1985).
    Article CAS Google Scholar
  13. Miyata, A., Toshimori, T., Kangawa, K. & Matsuo, H. Biochem. biophys. Res. Commun. 142, 461–467 (1987).
    Article CAS Google Scholar
  14. Minamino, N., Kangawa, K. & Matsuo, H. Biochem. biophys. Res. Commun. 130, 1078–1085 (1985).
    Article CAS Google Scholar
  15. de Bold, A. J., Borenstein, H. B., Veress, A. T. & Sonnenberg, H. Life Sci. 28, 89–94 (1981).
    Article CAS Google Scholar
  16. Kamber, B. et al. Helv. chim. Acta 63, 899–915 (1980).
    Article CAS Google Scholar

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Author notes

  1. Hisayuki Matsuo: To whom correspondence should be addressed.

Authors and Affiliations

  1. Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki, 889-16, Japan
    Tetsuji Sudoh, Kenji Kangawa, Naoto Minamino & Hisayuki Matsuo

Authors

  1. Tetsuji Sudoh
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  2. Kenji Kangawa
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  3. Naoto Minamino
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  4. Hisayuki Matsuo
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Sudoh, T., Kangawa, K., Minamino, N. et al. A new natriuretic peptide in porcine brain.Nature 332, 78–81 (1988). https://doi.org/10.1038/332078a0

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