A novel viral oncogene with structural similarity to phospholipase C (original) (raw)
- Letter
- Published: 17 March 1988
Nature volume 332, pages 272–275 (1988)Cite this article
- 978 Accesses
- 695 Citations
- 7 Altmetric
- Metrics details
Abstract
Numerous oncogenes have been isolated from acutely transforming retroviruses. To date, the products of these viral oncogenes have been protein kinases, nuclear proteins, growth factors, or GTP-binding proteins1,2. We have cloned the previously uncharacterized avian sarcoma virus CT10 and sequenced its genome. This virus encodes a protein, p47_gag-crk_, that has blocks of sequence similarity to the amino-terminal, non-catalytic region of the non-receptor class of tyrosine kinases. In addition, the structure of p47_gag-crk_ has striking similarity to a 180-amino acid region of bovine brain phospholipase C. Biochemical data suggest that p47_gag-crk_ activates one or several endogenous tyrosine kinases.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Bishop, J. M. Cell 42, 23–38 (1985).
Article CAS Google Scholar - Bishop, J. M. & Varmus, H. in RNA Tumor Viruses, Molecular Biology of Tumor Viruses Vol. 2 (cds Weiss, R., Teich, N., Varmus, H. & Coffin, J.) 249–356 (Cold Spring Harbor Laboratories, 1985).
Google Scholar - Burk, D. et al. J. natn. Cancer Inst. 2, 201–240 (1941).
CAS Google Scholar - Claude, A., Porter, K. R. & Pickels, E. G. Cancer Res. 7, 421–429 (1947).
Google Scholar - Neckameyer, W. S. & Wang, L.-H. J. Virol. 50, 914–921 (1984).
CAS PubMed PubMed Central Google Scholar - Mayer, B. J. et al. J. Virol. 60, 858–867 (1986).
CAS PubMed PubMed Central Google Scholar - Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratories, 1982).
Google Scholar - Cross, F. R. & Hanafusa, H. Cell 34, 597–607 (1983).
Article CAS Google Scholar - Coffin, J. in RNA Tumor Viruses, Molecular Biology of Tumor Viruses Vol. 2 (eds Weiss, R., Teich, N., Varmus, H. & Coffin, J.) 17–73 (Cold Spring Harbor Laboratories, 1985).
Google Scholar - Takeya, T., Feldman, R. A. & Hanafusa, H. J. Virol. 44, 1–11 (1982).
CAS PubMed PubMed Central Google Scholar - Schwartz, D. E., Tizard, R. & Gilbert, W. Cell 32, 853–869 (1983).
Article CAS Google Scholar - Lerner, T. L. & Hanafusa, H. J. Virol. 49, 549–556 (1984).
CAS PubMed PubMed Central Google Scholar - Bizub, D., Katz, R. A. & Skalka, A. M. J. Virol 49, 557–565 (1984).
CAS PubMed PubMed Central Google Scholar - Hunter, T. & Cooper, J. A. A. Rev. Biochem. 54, 897–930 (1985).
Article CAS Google Scholar - Stahl, M., Ferenz, C., Kelleher, K., Kriz, R. & Knopf, J. Nature 332, 269–272 (1988).
Article ADS CAS Google Scholar - Wang, J. Y. J. Molec. cell. Biol. 5, 3640–3643 (1985).
Article CAS Google Scholar - Hamaguchi, M., Grandori, C. & Hanafusa, H. Molec. cell. Biol. (submitted).
- Berridge, M. J. A. Rev. Biochem. 56, 159–193 (1987).
Article CAS Google Scholar - Majerus, P. W. et al. Science 234, 1519–1526 (1986).
Article ADS CAS Google Scholar - Chen, E. Y. & Seeburg, P. H. DNA 4, 165–170 (1985).
Article CAS Google Scholar - Takeya, T. & Hanafusa, H. Cell 32, 881–890 (1983).
Article CAS Google Scholar - Ben-Neriah, Y., Bernards, A., Paskind, M., Daley, G. Q. & Baltimore, D. Cell 44, 577–586 (1986).
Article CAS Google Scholar - Garber, E. A., Mayer, B. J., Jove, R. & Hanafusa, H. J. Virol. 61, 354–360 (1987).
CAS PubMed PubMed Central Google Scholar - Cooper, J. A. & Hunter, T. Molec. cell. Biol. 1, 165–178 (1981).
Article CAS Google Scholar - Sadowski, I., Stone, J. & Pawson, T. Molec. cell. Biol. 6, 4396–4408 (1986).
Article CAS Google Scholar - Collett, M. S. & Erikson, R. L. Proc. natn. Acad Sci. U.S.A. 75, 2021–2025 (1978).
Article ADS CAS Google Scholar
Author information
Authors and Affiliations
- The Rockefeller University, New York, New York, 10021, USA
Bruce J. Mayer, Michinari Hamaguchi & Hidesaburo Hanafusa
Authors
- Bruce J. Mayer
You can also search for this author inPubMed Google Scholar - Michinari Hamaguchi
You can also search for this author inPubMed Google Scholar - Hidesaburo Hanafusa
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Mayer, B., Hamaguchi, M. & Hanafusa, H. A novel viral oncogene with structural similarity to phospholipase C.Nature 332, 272–275 (1988). https://doi.org/10.1038/332272a0
- Received: 30 December 1987
- Accepted: 28 January 1988
- Issue Date: 17 March 1988
- DOI: https://doi.org/10.1038/332272a0