MHC polymorphism pre-dating speciation (original) (raw)

Nature volume 335, pages 265–267 (1988)Cite this article

Abstract

Two features distinguish the polymorphism of the major histocom-patibility complex (MHC) loci from that of other loci: its high diversity and the large genetic distance between MHC alleles1,2. More than 100 alleles exist in natural populations in the mouse at each of the functional class I and class II alleles, all alleles occurring at frequencies that cannot be explained by recurrent mutations2,3. Some of the alleles differ by approximately 70 nucleo-tides in the coding region alone and some of the products of the allelic genes differ by more than 50 amino acids4. It has generally been assumed that these differences accumulated after species inception. Here, we present evidence for an alternative explanation of the origin of MHC polymorphism: a large part of the MHC polymorphism pre-dates speciation and is passed on from species to species5,6. We describe allelic differences that must have arisen before the separation of mice and rats from a common ancestor more than 10 million years ago.

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References

  1. Klein, J. Natural History of the Major Histocompatibility Complex (Wiley, New York, 1986).
    Google Scholar
  2. Klein, J. & Figueroa, F. CRC Crit. Rev. Immun. 6, 295–386 (1986).
    CAS Google Scholar
  3. Klein, J. & Figueroa, F. Immun. Rev. 60, 23–57 (1981).
    Article CAS Google Scholar
  4. Möller, G. (ed.) Immun. Rev. 84, 85 (1985).
  5. Klein, J. in Immunology 80 (eds Fongereau, K. & Dausset, J.) 239–253 (1980).
    Google Scholar
  6. Klein, J. Hum. Immun. 19, 155–162 (1987).
    Article CAS Google Scholar
  7. Zinkernagel, R. M. & Doherty, P. C. Adv. Immun. 207, 51–177 (1980).
    Google Scholar
  8. Figueroa, F. & Klein, J. in H-2 Genes, Products, and Function (ed. David, C. S.) 61–76 (Plenum, New York, 1988).
    Google Scholar
  9. McIntyre, K. & Seidman, J. Nature 308, 551–553 (1984).
    Article ADS CAS Google Scholar
  10. Potter, M., Nadeau, J. H. & Cancro, M. P. The Wild Mouse in Immunology (Springer, Berlin, 1986).
    Book Google Scholar
  11. Fccles, S. J. & McMaster, R. Immunogenetics 22, 613–663 (1985).
    Google Scholar
  12. Luckett, W. P. & Hartenberger, J. L. Evolutionary Relationships Among Rodents: A Multi- disciplinary Analysis (Plenum, New York, 1985).
    Book Google Scholar
  13. Flynn, L. J. et al. C.R.Acad. Sci. (II) 32, 917–927 (1986).
    Google Scholar
  14. Britten, R. J. Science 231, 1393–1398 (1986).
    Article ADS CAS Google Scholar
  15. McConnell, T. J., Talbot, W. S., McIndoe, R. A. & Wakeland, E. K. Nature 332, 651–654 (1988).
    Article ADS CAS Google Scholar
  16. Klein, J., Kasahara, M., Mayer, W. & Figueroa, F. Science (submitted).
  17. Mayer, W. E., Klein, D., Jonkers, M. & Klein, J. EMBO J. (in the press).
  18. Hughes, A. L. & Nei, M. Nature 335, 167–170 (1988).
    Article ADS CAS Google Scholar
  19. Angelini, G., de Preval, C., Gorski, J. & Mach, B. Proc. natn. Acad. Sci. U.S.A. 83, 4489–4493 (1986).
    Article ADS CAS Google Scholar
  20. Kasahara, M., Figueroa, F. & Klein, J. Proc. natn. Acad. Sci. U.S.A 84, 3325–3328 (1987).
    Article ADS CAS Google Scholar
  21. Sanger, F., Nicklen, S. & Carlson, R. Proc. natn. Acad. Sci. U.S.A. 77, 5463–5467 (1977).
    Article ADS Google Scholar

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Authors and Affiliations

  1. Max-Planck-Institut für Biologic, Abteilung Immungenetik, Corrensstr. 42, D-7400, Tübingen, FRG
    Felipe Figueroa & Jan Klein
  2. Universitätskliniken Göttingen, Zentrum für Hygiene und Humangenetik, Abteilung Immungenetik, Goslar Str. 12d, D-3400, Göttingen, FRG
    Eberhardt Gúnther
  3. Department of Microbiology and Immunology, University of Miami, School of Medicine (R-138), PO Box 016960, Miami, Florida, 33101, USA
    Jan Klein

Authors

  1. Felipe Figueroa
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  2. Eberhardt Gúnther
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  3. Jan Klein
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Figueroa, F., Gúnther, E. & Klein, J. MHC polymorphism pre-dating speciation.Nature 335, 265–267 (1988). https://doi.org/10.1038/335265a0

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