The mas oncogene encodes an angiotensin receptor (original) (raw)
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- Published: 29 September 1988
Nature volume 335, pages 437–440 (1988)Cite this article
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Abstract
The class of receptors coupled to GTP-binding proteins share a conserved structural motif which is described as a 'seven-transmembrane segment'1 following the prediction that these hydrophobic segments form membrane-spanning α-helices. Identified examples include the mammalian opsins2, α1-, α2-, β1- and β2-adrenergic receptors3, the muscarinic receptor family4,5, the 5-HT1C-receptor6, and the substance-K receptor7. In addition, two mammalian genes have been identified that code for predicted gene products with sequence similarity to these receptors, but whose ligand specificity is unknown namely, G21 (ref. 8) and the mas oncogene9. The mas oncogene shows the greatest sequence similarity to the substance-K receptor, and on this basis it was predicted that it would encode a peptide receptor with mitogenic activity which would act through the inositol lipid signalling pathways10,11. The mas oncogene product was transiently expressed in Xenopus oocytes, and stably expressed in a transfected mammalian cell line. The results demonstrate that the mas gene product is a functional angiotensin receptor.
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References
- Dohlman, W. G., Caron, M. G. & Lefkowitz, R. J. Biochemistry 26, 2657–2664 (1987).
Article CAS Google Scholar - Nathans, J. A. Rev. Neurosci 10, 161–194 (1987).
Article Google Scholar - Leftowitz, R. J. & Caron, M. G. J. biol. Chem. 263, 4993–4996 (1988).
Google Scholar - Kubo, T. et al. Nature 321, 411–416 (1986).
Article ADS Google Scholar - Bonner, T. I., Buckley, N. J., Young, A. C. & Brann, M. R. Science 237, 527–532 (1987).
Article ADS CAS Google Scholar - Julius, D., MacDermott, A. B., Axel, R. & Jessell, P. M. Science 241, 558–564 (1988).
Article ADS CAS Google Scholar - Masu, Y. et al. Nature 329, 836–838 (1987).
Article ADS CAS Google Scholar - Kobilka, B. K. et al. Nature 329, 75–79 (1987).
Article ADS CAS Google Scholar - Young, D., Waitches, G., Birchmeier, C., Fasano, G. & Wigler, M. Cell 45, 711–719 (1986).
Article CAS Google Scholar - Hanley, M. R. & Jackson, T. R. Nature 329, 766–767 (1987).
Article ADS CAS Google Scholar - Hanley, M. R. Neuron 1, 175–182 (1988).
Article CAS Google Scholar - Corps, A. N., Rees, L. H. & Brown, K. D. Biochem. J. 231, 781–784 (1985).
Article CAS Google Scholar - Regoli, D. Can. J. Physiol. Pharmacol. 57, 129–139 (1979).
Article CAS Google Scholar - Gillo, B., Lass, Y., Nadler, E. & Oran, Y. J. Physiol., Lond. 392, 349–361 (1987).
Article CAS Google Scholar - Jackson, T. R., Hallam, T. J., Downes, C. P. & Hanley, M. R. EMBO J. 6, 49–54 (1987).
Article CAS Google Scholar - Grynkiewicz, G., Poenie, M. & Tsien, R. Y. J. biol. Chem. 260, 3440–3450 (1985).
CAS Google Scholar - Young, D., O'Neill, K., Jessell, T. & Wigler, M. Proc. natn. Acad. Sci. U.S.A. 85, 5339–5342 (1988).
Article ADS CAS Google Scholar - Burt, D. R. in Neurotransmitter Receptors Part 1, Series B, 9 (eds Enna, S. J. & Yamamura, H. I.) 152–205 (Chapman and Hall, London, 1980).
Google Scholar - Hanley, M. R. Nature 315, 14–15 (1985).
Article ADS CAS Google Scholar - Zachary, I., Woll, P. J. & Rozengurt, E. Devl Biol. 124, 295–308 (1987).
Article CAS Google Scholar - Rabin, M. et al. Oncogene Res. 1, 169–178 (1988).
Google Scholar - Ferrario, C. M. Hypertension 5, V73–V79 (1983).
Article CAS Google Scholar - Connell, J. M. C. Trends pharmacol. Sci. 7, 412–418 (1986).
Article Google Scholar - Melton, D. A. et al. Nucleic Acids Res. 12, 7035–7056 (1984).
Article CAS Google Scholar - White, M. M. et al. Proc. natn. Acad. Sci. U.S.A. 82, 4852–4856 (1985).
Article ADS CAS Google Scholar - Wigler, M. et al. Proc. natn. Acad. Sci. U.S.A. 76, 1373–1376 (1979).
Article ADS CAS Google Scholar - Jackson, T. R., Patterson, S. I., Thastrup, O. & Hanley, M. R. Biochem. J. 253, 81–86 (1988).
Article CAS Google Scholar - Goedert, M. EMBO J. 6, 3627–3632 (1987).
Article CAS Google Scholar - Fargin, A. et al. Nature 335, 358–360 (1988).
Article ADS CAS Google Scholar
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Author notes
- L. A. C. Blair
Present address: Department of Pharmacology, University of California at San Diego, La Jolla, California, 92093, USA - M. Goedert: Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
- M. R. Hanley: Author to whom correspondence should be addressed.
Authors and Affiliations
- Medical Research Council Molecular Neurobiology Unit,
T. R. Jackson, L. A. C. Blair, J. Marshall, M. Goedert & M. R. Hanley
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- T. R. Jackson
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Jackson, T., Blair, L., Marshall, J. et al. The mas oncogene encodes an angiotensin receptor.Nature 335, 437–440 (1988). https://doi.org/10.1038/335437a0
- Received: 01 August 1988
- Accepted: 24 August 1988
- Issue Date: 29 September 1988
- DOI: https://doi.org/10.1038/335437a0