Positive selection of antigen-specific T cells in thymus by restricting MHC molecules (original) (raw)
- Letter
- Published: 20 October 1988
Nature volume 335, pages 730–733 (1988)Cite this article
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Abstract
Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cell receptor (TCR)1,2. CD4 and CDS molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling3,4. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the αβ TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen5. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting class I MHC molecule.
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Authors and Affiliations
- Basel Institute for Immunology, 487 Grenzacherstrasse, CH-4058, Basel, Switzerland
Pawel Kisielow, Hung Sia Teh & Harald von Boehmer - Central Research Units, F. Hoffmann–La Roche & Co. Ltd, CH-4002, Basel, Switzerland
Horst Blüthmann - The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Pawel Kisielow - Department of Microbiology, University of British Columbia, Vancouver, V6T 1W5, Canada
Hung Sia Teh
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- Pawel Kisielow
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Kisielow, P., Teh, H., Blüthmann, H. et al. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules.Nature 335, 730–733 (1988). https://doi.org/10.1038/335730a0
- Received: 25 July 1988
- Accepted: 12 September 1988
- Issue Date: 20 October 1988
- DOI: https://doi.org/10.1038/335730a0