A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site (original) (raw)

Nature volume 341, pages 205–209 (1989)Cite this article

Abstract

An engineered precursor protein that sticks in the import site of isolated yeast mitochondria can be specifically photo-crosslinked to a mitochondrial outer-membrane protein of relative molecular mass 42,000 (42K). This protein (termed import-site protein 42 or ISP 42) is exposed on the mitochondrial surface; antibodies against it block protein import into mitochondria. ISP 42 is the first identified component of the putative transmembrane machinery that imports proteins into mitochondria.

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Author notes

  1. Alison Baker
    Present address: Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK
  2. Josef Brunner: Swiss Federal Institute of Technology (ETH), CH-8092 Zürich, Switzerland

Authors and Affiliations

  1. Biocenter, University of Basel, CH-4056, Basel, Switzerland
    Dietmar Vestweber, Josef Brunner, Alison Baker & Gottfried Schatz

Authors

  1. Dietmar Vestweber
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  2. Josef Brunner
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  3. Alison Baker
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  4. Gottfried Schatz
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Vestweber, D., Brunner, J., Baker, A. et al. A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site.Nature 341, 205–209 (1989). https://doi.org/10.1038/341205a0

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