A serine/threonine kinase gene defective in Peutz–Jeghers syndrome (original) (raw)

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Acknowledgements

This study was aided by grants from the Helsinki University Central Hospital, the Academy of Finland, the Finnish Cancer Society, the Finnish Medical Society Duodecim, the Ida Montin Foundation, the Jalmari and Rauha Ahokas Foundation, the 350th Anniversary Foundation of the University of Helsinki, Leiras, the Emil Aaltonen Foundation, the UK Cancer Research Campaign, the ICRF, the Institute of Cancer Research, the U.S. Department of Energy, the Otago Medical School Bequest Funds, the Cancer Society of New Zealand and The Wellington Division of the Cancer Society of New Zealand. We thank K. Honkanen, M. Veini, T. Kosonen, S. Lindh, S. Lindroos, K. Collin, A. Georgescu, L.Gordon and R. Hamoudi for technical assistance; W. El-Rifai, K. Virtaneva, S. Ranta and S. Ezer for help with methodology; A. Moisio for control samples; D. Jenne for unpublished mapping data; the many PJS families for their collaboration; and the following clinicians for PJS samples: I. Ellis, S. Hodgson, T.Iwama, S. Loff, P. Zauber, C. Marchere, J. Sampson, S. Davies, I. Talbot, J. Wyke, R. Houlston, O. Suomalainen, F.M. Giardiello, S. R. Hamilton, S. B. Gruber, C. Eng, S. A. Lynch, A. Hunter and G. Mettler, and the polyposis registry, St Mark's Hospital.

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Authors and Affiliations

  1. Departments of Medical Genetics,
    Akseli Hemminki, Egle Avizienyte, Stina Roth, Anu Loukola, Maria Aminoff, Pia Höglund, Paula Kristo, Katarina Pelin, Maaret Ridanpää, Reijo Salovaara, Albert de la Chapelle & Lauri A. Aaltonen
  2. Pathology, Haartman Institute, University of Helsinki, PO Box 21, Haartmaninkatu 3, 00014, Finland
    Reijo Salovaara
  3. Department of Pathology, Dunedin School of Medicine, PO Box 913, Dunedin, New Zealand
    David Markie & Tumi Toro
  4. Section of Cancer Genetics, Haddow Laboratories, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Ian Tomlinson, Graham Bignell, William Warren & Michael R. Stratton
  5. Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Ian Tomlinson
  6. Second Department of Surgery, Helskinki University Central Hospital, Helsinki, Haartmaninkatu 4, 00290, Finland
    Heikki Järvinen
  7. Folkhlsan Institute of Genetics, Helsinki, Mannerheimintie 97, 00280, Finland
    Maria Aminoff, Katarina Pelin & Maaret Ridanpää
  8. ICRF Cancer and Immunogenetics Laboratory, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Walter Bodmer
  9. Inserm U434, Fondation Jean Dausset-CEPH F75010 Paris, France
    Sylviane Olschwang
  10. Human Genome Center, L-452, Lawrence Livermore National Laboratory, Livermore, California, 94550, USA
    Anne S. Olsen
  11. Comprehensive Cancer Center, Ohio State University, 420 W 12th Avenue, Columbus, Ohio, 43210, USA
    Albert de la Chapelle

Authors

  1. Akseli Hemminki
  2. David Markie
  3. Ian Tomlinson
  4. Egle Avizienyte
  5. Stina Roth
  6. Anu Loukola
  7. Graham Bignell
  8. William Warren
  9. Maria Aminoff
  10. Pia Höglund
  11. Heikki Järvinen
  12. Paula Kristo
  13. Katarina Pelin
  14. Maaret Ridanpää
  15. Reijo Salovaara
  16. Tumi Toro
  17. Walter Bodmer
  18. Sylviane Olschwang
  19. Anne S. Olsen
  20. Michael R. Stratton
  21. Albert de la Chapelle
  22. Lauri A. Aaltonen

Corresponding author

Correspondence toLauri A. Aaltonen.

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Hemminki, A., Markie, D., Tomlinson, I. et al. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome.Nature 391, 184–187 (1998). https://doi.org/10.1038/34432

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