Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit (original) (raw)

Nature volume 347, pages 667–669 (1990)Cite this article

Abstract

MICE carrying mutations at the W (Dominant white spotting) and SI (Steel) loci develop abnormalities in three independent systems: neural crest-derived melanocytes, primordial germ cells and haematopoietic stem cells. Consequently, homozygotes of viable mutant alleles have white coats and are sterile and severely anaemic. Tissue recombination studies predict that the W gene is expressed cell autonomously, whereas the product of the SI locus affects the microenvironment in which the stem cells migrate, proliferate and differentiate1–6. The W locus encodes the proto-oncogene c-kit, a member of the tyrosine kinase receptor family7,8.The haematopoietic growth factor SCF (stem cell factor) has been identified as the product of the SI locus and a ligand for c-kit9–11. Here, we report that SCF is expressed during embryogenesis in cells associated with both the migratory pathways and homing sites of melanoblasts, germ cells and haematopoietic stem cells. Both SCF and c-kit are also expressed in a variety of other tissues, including the brain and spinal cord, suggesting that the receptor–ligand system has additional roles in embryogenesis.

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Authors and Affiliations

  1. Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee, 37232-2172, USA
    Yasuhisa Matsui & Brigid L. M. Hogan
  2. Amgen Incorporated, Amgen Center, Thousand Oaks, California, 91320, USA
    Kristina M. Zsebo

Authors

  1. Yasuhisa Matsui
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  2. Kristina M. Zsebo
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  3. Brigid L. M. Hogan
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Matsui, Y., Zsebo, K. & Hogan, B. Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit.Nature 347, 667–669 (1990). https://doi.org/10.1038/347667a0

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