CCR5 is characteristic of Th1 lymphocytes (original) (raw)

• Scientific Correspondence
• Published: 22 January 1998
• Mariagrazia Uguccioni1,
• Lorenza Bordoli1,
• Marco Baggiolini1,
• Bernhard Moser1,
• Carlo Chizzolini3 &
• …
• Jean-Michel Dayer3

Nature volume 391, pages 344–345 (1998) Cite this article

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Abstract

CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (23). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones4.

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Authors and Affiliations

1. Theodor-Kocher Institute, University of Bern, P.O. Box CH-3000 Bern 9, Switzerland
   Mariagrazia Uguccioni, Lorenza Bordoli, Marco Baggiolini & Bernhard Moser
2. Division of Rheumatology, University Hospital, CH-3010 Bern, Switzerland
   Pius Loetscher
3. Division of Immunology and Allergy, University Hospital, CH-1211, Geneva, Switzerland
   Carlo Chizzolini & Jean-Michel Dayer

Authors

1. Pius Loetscher
2. Mariagrazia Uguccioni
3. Lorenza Bordoli
4. Marco Baggiolini
5. Bernhard Moser
6. Carlo Chizzolini
7. Jean-Michel Dayer

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Loetscher, P., Uguccioni, M., Bordoli, L. et al. CCR5 is characteristic of Th1 lymphocytes.Nature 391, 344–345 (1998). https://doi.org/10.1038/34814

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• Issue date: 22 January 1998
• DOI: https://doi.org/10.1038/34814