Interferon-γ elicits arteriosclerosis in the absence of leukocytes (original) (raw)

Nature volume 403, pages 207–211 (2000)Cite this article

Abstract

Atherosclerosis and post-transplant graft arteriosclerosis are both characterized by expansion of the arterial intima as a result of the infiltration of mononuclear leukocytes, the proliferation of vascular smooth muscle cells (VSMCs) and the accumulation of extracellular matrix1,2,3. They are also associated with the presence of the immunomodulatory cytokine interferon-γ (IFN-γ)2,3. Moreover, in mouse models of atheroma formation or allogeneic transplantation, the serological neutralization4 or genetic absence5,6,7,8 of IFN-γ markedly reduces the extent of intimal expansion. However, other studies have found that exogenous IFN-γ inhibits cultured VSMC proliferation9,10,11,12,13,14 and matrix synthesis15, and reduces intimal expansion in response to mechanical injury16,17,18. This discrepancy is generally explained by the idea that IFN-γ either directly activates macrophages, or, by increasing antigen presentation, indirectly activates T cells within the lesions of atherosclerosis and graft arteriosclerosis. These activated leukocytes are thought to express the VSMC-activating cytokines1,2,3 and cell-surface molecules19 that cause the observed arteriosclerotic responses. Here we have inserted pig and human arteries into the aorta of immunodeficient mice, and we show that IFN-γ can induce arteriosclerotic changes in the absence of detectable immunocytes by acting on VSMCs to potentiate growth-factor-induced mitogenesis.

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Acknowledgements

This work was supported by grants from the American Heart Association (G.T.) and the NIH (J.S.P.). R.W.K. received a fellowship award for the Thoracic Surgery Foundation for Research and Education, and J.S.S. was supported by a career development award from the Dermatology Foundation.

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Authors and Affiliations

  1. Interdepartmental Program in Vascular Biology and Transplantation, and the Departments of, Boyer Center for Molecular Medicine,
    George Tellides, Denis A. Tereb, Nancy C. Kirkiles-Smith, Richard W. Kim, Jeffrey S. Schechner & Jordan S. Pober
  2. the Departments of Surgery,
    George Tellides, Denis A. Tereb, Nancy C. Kirkiles-Smith, Richard W. Kim, Jean H. Wilson & Marc I. Lorber
  3. the Departments of Dermatology,
    Jeffrey S. Schechner & Jordan S. Pober
  4. the Departments of Pathology and,
    Jordan S. Pober
  5. the Departments of Immunobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, 06510, Connecticut, USA
    Jordan S. Pober

Authors

  1. George Tellides
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  2. Denis A. Tereb
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  3. Nancy C. Kirkiles-Smith
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  4. Richard W. Kim
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  5. Jean H. Wilson
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  6. Jeffrey S. Schechner
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  7. Marc I. Lorber
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  8. Jordan S. Pober
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Correspondence toGeorge Tellides.

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Tellides, G., Tereb, D., Kirkiles-Smith, N. et al. Interferon-γ elicits arteriosclerosis in the absence of leukocytes.Nature 403, 207–211 (2000). https://doi.org/10.1038/35003221

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