Low fidelity DNA synthesis by human DNA polymerase-η (original) (raw)

References

  1. Friedberg,E. C. & Gerlach,V. L. Novel DNA polymerases offer clues to the molecular basis of mutagenesis. Cell 98, 413–416 (1999).
    Article CAS Google Scholar
  2. Woodgate,R. A plethora of lesion-replicating DNA polymerases. Genes Dev. 13, 2191–2195 (1999).
    Article CAS Google Scholar
  3. Johnson,R. E., Washington,M. T., Prakash, S. & Prakash,L. Bridging the gap: A family of novel DNA polymerases that replicate faulty DNA. Proc. Natl Acad. Sci. USA 96, 12224 –12226 (1999).
    Article ADS CAS Google Scholar
  4. Ogi,T., Kato,T. Jr, Kato, T. & Ohmori,H. Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein DinB. Genes Cells 4, 607–618 (1999).
    Article CAS Google Scholar
  5. Masutani,C. et al. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η. Nature 399, 700–704 (1999).
    Article ADS CAS Google Scholar
  6. Johnson,R. E., Kondratick,C. M., Prakash, S. & Prakash,L. hRAD30 mutations in the variant form of xeroderma pigmentosum. Science 285, 263–265 ( 1999).
    Article CAS Google Scholar
  7. Maher,V. M., Ouellette,L. M., Curren,R. D. & McCormick,J. J. Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells. Nature 261 , 593–595 (1976).
    Article ADS CAS Google Scholar
  8. Myhr,B. C., Turnbull,D. & DiPaolo, J. A. Ultraviolet mutagenesis of normal and xeroderma pigmentosum variant human fibroblasts. Mutat. Res. 62, 341–353 (1979).
    Article CAS Google Scholar
  9. Wang,Y. C., Maher,V. M. & McCormick, J. J. Xeroderma pigmentosum variant cells are less likely than normal cells to incorporate dAMP opposite photoproducts during replication of UV-irradiated plasmids. Proc. Natl Acad. Sci. USA 88, 7810–7814 (1991).
    Article ADS CAS Google Scholar
  10. Wang,Y. C., Maher,V. M., Mitchell,D. L. & McCormick,J. J. Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cell reflects abnormal, error-prone replication on a template containing photoproducts. Mol. Cell. Biol. 13, 4276 –4283 (1993).
    Article CAS Google Scholar
  11. Waters,H. L., Seetharam,S., Seidman,M. M. & Kraemer,K. H. Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells. J. Invest. Dermatol. 101, 744–748 (1993).
    Article CAS Google Scholar
  12. Masutani,C. et al. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J. 18, 3491–3501 ( 1999).
    Article CAS Google Scholar
  13. Johnson,R. E., Prakash,S. & Prakash, L. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Pol η. Science 283, 1001–1004 (1999).
    Article ADS CAS Google Scholar
  14. Roberts,J. D., Bebenek,K. & Kunkel,T. A. The accuracy of reverse transcriptase from HIV-1. Science 242, 1171–1173 ( 1988).
    Article ADS CAS Google Scholar
  15. Osheroff,W. P. et al. The fidelity of DNA polymerase beta during distributive and processive DNA synthesis. J. Biol. Chem. 274, 3642–3650 (1999).
    Article CAS Google Scholar
  16. Bebenek,K. & Kunkel,T. A. Analyzing the fidelity of DNA polymerases. Methods Enzymol. 262, 217– 232 (1995).
    Article CAS Google Scholar
  17. Washington,M. T., Johnson,R. E., Prakash,S. & Prakash,L. Fidelity and processivity of Saccharomyces cereivisiae DNA polymerase η. J. Biol. Chem. 274, 36835– 36838 (1999).
    Article CAS Google Scholar
  18. Perrino,F. W. & Loeb,L. A. Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α. J. Biol. Chem. 264, 2898– 2905 (1989).
    CAS PubMed Google Scholar
  19. Wang,H., Lawrence,C. W., Li,G. M. & Hays,J. B. Specific binding of human MSH2·MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases. J. Biol. Chem. 274, 16894– 16900 (1999).
    Article CAS Google Scholar
  20. McDonald,J. P., Levine,A. S. & Woodgate, R. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics 147, 1557–1568 ( 1997).
    CAS PubMed PubMed Central Google Scholar
  21. Kang,X. L., Yadao,F., Gietz,R. D. & Kunz,B. A. Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G.C to T.A transversions as well as transposition of the Ty element: implications for the control of spontaneous mutation. Genetics 130 , 285–294 (1992).
    CAS PubMed PubMed Central Google Scholar
  22. Clairmont,C. A. et al. The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells. Proc. Natl Acad. Sci. USA 96, 9580–9585 ( 1999).
    Article ADS CAS Google Scholar
  23. Kim,S. R. et al. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Proc. Natl Acad. Sci. USA 94, 13792–13797 (1997).
    Article ADS CAS Google Scholar
  24. Kunkel,T. A. & Bebenek,K. DNA replication fidelity. Annu. Rev. Biochem. 69, (in the press).
  25. Nelson,J. R., Lawrence,C. W. & Hinkle, D. C. Thymine-thymine dimer bypass by yeast DNA polymerase ζ. Science 272, 1646–1649 (1996).
    Article ADS CAS Google Scholar
  26. Lewis,D. A. et al. Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase. J. Biol. Chem. 274, 32924–32930 (1999).
    Article CAS Google Scholar
  27. Bebenek,K., Joyce,C. M., Fitzgerald,M. P. & Kunkel,T. A. The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. J. Biol. Chem. 265, 13878 –13887 (1990).
    CAS PubMed Google Scholar
  28. Roberts,J. D. & Kunkel,T. A. in DNA Replication in Eukaryotic Cells: Concepts, Enzymes and Systems (ed. Pamphilis, M. D.) 217 –247 (Cold Spring Harbor Laboratory Press, New York, 1996).
    Google Scholar

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