- Schneller, M., Vuori, K. & Ruoslahti, E. αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF. EMBO J. 16, 5600–5607 (1997).
Article CAS Google Scholar
- Miyamoto, S., Teremoto, H., Gutkind, J. S. & Yamada, K. M. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633–1642 (1996).
Article CAS Google Scholar
- Howe, A., Aplin, A. E., Alahari, S. K. & Juliano, R. L. Integrin signaling and cell growth control. Curr. Opin. Cell Biol. 10, 220–231 (1998).
Article CAS Google Scholar
- Giancotti, F. G. & Ruoslahti, E. Integrin signaling . Science 285, 1028–1032 (1999).
Article CAS Google Scholar
- Schwartz, M. A. & Baron, V. Interactions between mitogenic stimuli, or, a thousand and one connections. Curr. Opin. Cell Biol. 11, 197–202 (1999).
Article CAS Google Scholar
- Hildebrand, J. D., Schaller, M. D. & Parsons, J. T. Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions. J. Cell Biol. 123, 993– 1005 (1993).
Article CAS Google Scholar
- Tachibana, K., Sato, T., D’Avirro, N. & Morimoto, C. Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK. J. Exp. Med. 182, 1089–1100 (1995).
Article CAS Google Scholar
- Liu, S. et al. Binding of paxillin to alpha 4 integrins modifies integrin-dependent biological responses. Nature 402, 676– 681 (1999).
Article CAS Google Scholar
- Chen, H. C. et al. Interaction of focal adhesion kinase with cytoskeletal protein talin. J. Biol. Chem. 270, 16995– 16999 (1995).
Article CAS Google Scholar
- Schlaepfer, D. D. & Hunter, T. Evidence for in vivo phosphorylation of the Grb 2 SH 2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol. Cell. Biol. 16, 5623–5633 (1996).
Article CAS Google Scholar
- Schlaepfer, D. D., Hauck, C. R. & Sieg, D. J. Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol. 71, 435– 478 (1999).
Article CAS Google Scholar
- Tamura, M. et al. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614 –1617 (1998).
Article CAS Google Scholar
- Gu, J. et al. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol. 146, 389 –404 (1999).
Article CAS Google Scholar
- Sieg, D. J. et al. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration. EMBO J. 17, 5933–5947 (1998).
Article CAS Google Scholar
- Sieg, D. J., Hauck, C. R. & Schlaepfer, D. D. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J. Cell Sci. 112 , 2677–2691 (1999).
CAS PubMed Google Scholar
- Owen, J. D., Ruest, P. J., Fry, D. W. & Hanks, S. K. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk 2. Mol. Cell Biol. 19, 4806–4818 (1999).
Article CAS Google Scholar
- Cary, L. A., Han, D. C., Polte, T. R., Hanks, S. K. & Guan, J.-L. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J. Cell Biol. 140, 211–221 (1998).
Article CAS Google Scholar
- Gilmore, A. P. & Romer, L. H. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell 7, 1209 –1224 (1996).
Article CAS Google Scholar
- George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H. & Hynes, R. O. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin . Development 119, 1079– 1091 (1993).
CAS PubMed Google Scholar
- Furuta, Y. et al. Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene 11 , 1989–1995 (1995).
CAS PubMed Google Scholar
- Ilic, D. et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539–544 (1995).
Article CAS Google Scholar
- Chen, H. C. & Guan, J. L. The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor. Eur. J. Biochem. 235, 495–500 (1996).
Article CAS Google Scholar
- Salazar, E. P. & Rozengurt, E. Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells. J. Biol. Chem. 274, 28371–28378 (1999).
Article CAS Google Scholar
- Schlaepfer, D. D., Jones, K. C. & Hunter, T. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK 2/mitogen-activated protein kinase: Summation of both c-Src and FAK-initiated tyrosine phosphorylation events. Mol. Cell Biol. 18, 2571–2585 (1998).
Article CAS Google Scholar
- Chen, H. C., Appeddu, P. A., Isoda, H. & Guan, J. L. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J. Biol. Chem 271, 26329–26334 (1996).
Article CAS Google Scholar
- Manes, S. et al. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol. Cell Biol. 19, 3125–3135 (1999).
Article CAS Google Scholar
- Zhang, X. et al. Focal adhesion kinase promotes phospholipase C-gamma 1 activity . Proc. Natl Acad. Sci. USA 96, 9021– 9026 (1999).
Article CAS Google Scholar
- Han, D. C. & Guan, J. L. Association of focal adhesion kinase with grb7 and its role in cell migration. J. Biol. Chem. 274, 24425–24430 (1999).
Article CAS Google Scholar
- Schaller, M. D., Otey, C. A., Hildebrand, J. D. & Parsons, J. T. Focal adhesion kinase and paxillin bind peptides mimicking β integrin cytoplasmic domains. J. Cell Biol. 130, 1181–1187 (1995).
Article CAS Google Scholar
- Girault, J. A., Labesse, G., Mornon, J. P. & Callebaut, I. The N-termini of FAK and JAKs contain divergent band 4.1 domains. Trends Biochem. Sci. 24, 54–57 (1999).
Article CAS Google Scholar
- Lev, S. et al. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol. Cell. Biol. 19, 2278–2288 (1999).
Article CAS Google Scholar
- Richardson, A. & Parsons, J. T. A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK. Nature 380, 538– 540 (1996).
Article CAS Google Scholar
- Cicala, C. et al. Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelope. J. Immunol. 163, 420–426 (1999).
CAS PubMed Google Scholar
- Miao, H., Burnett, E., Kinch, M., Simon, E. & Wang, B. Activation of EphA2 kinase suppresses integrin function and causes focal adhesion kinase dephosphorylation. Nature Cell Biol. 2, 62–69 (2000).
Article CAS Google Scholar
- Fincham, V. J. & Frame, M. C. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17, 81–92 (1998).
Article CAS Google Scholar
- Brunton, V. G., Ozanne, B. W., Paraskeva, C. & Frame, M. C. A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. Oncogene 14, 283–293 (1997).
Article CAS Google Scholar
- Owens, L. V. et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res. 55, 2752– 2755 (1995).
CAS PubMed Google Scholar
- Kornberg, L. J. Focal adhesion kinase and its potential involvement in tumor invasion and metastasis. Head Neck 20, 745– 752 (1998).
Article CAS Google Scholar
- Agochiya, M. et al. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 18, 5646–5653 (1999).
Article CAS Google Scholar
- Schlaepfer, D. D., Broome, M. A. & Hunter, T. Fibronectin-stimulated signaling from a focal adhesion kinase- c-Src complex: involvement of the Grb 2, p130Cas, and Nck adaptor proteins. Mol. Cell Biol. 17, 1702–1713 (1997).
Article CAS Google Scholar