A triclosan-resistant bacterial enzyme (original) (raw)

Microbiology

Nature volume 406, pages 145–146 (2000) Cite this article

An Erratum to this article was published on 24 August 2000

Abstract

Triclosan is an antimicrobial agent that is widely used in a variety of consumer products and acts by inhibiting one of the highly conserved enzymes (enoyl-ACP reductase, or FabI) of bacterial fatty-acid biosynthesis. But several key pathogenic bacteria do not possess FabI, and here we describe a unique triclosan-resistant flavoprotein, FabK, that can also catalyse this reaction in Streptococcus pneumoniae. Our finding has implications for the development of FabI-specific inhibitors as antibacterial agents.

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Figure 1: FabK is an enoyl-ACP reductase.

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Authors and Affiliations

  1. Department of Biochemistry, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA
    Richard J. Heath & Charles O. Rock
  2. Department of Biochemistry, University of Tennessee, Memphis, 38105, Tennessee, USA
    Charles O. Rock

Authors

  1. Richard J. Heath
  2. Charles O. Rock

Corresponding author

Correspondence toCharles O. Rock.

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Heath, R., Rock, C. A triclosan-resistant bacterial enzyme.Nature 406, 145–146 (2000). https://doi.org/10.1038/35018162

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