Kinase regulation in inflammatory response (original) (raw)

Signalling pathways

Nature volume 406, pages 367–368 (2000)Cite this article

Abstract

The transcription factor NF-κB is a pivotal regulator of innate immune responses, whose activity is rapidly induced by proinflammatory stimuli, most notably the tumour-necrosis factor TNFα and interleukin-1, viruses, and components of bacterial cell walls[1](/articles/35019154#ref-CR1 "Rothwarf, D. M. & Karin, M. The NF-κ B Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus http://www.stke.org/cgi/content/fullOC_sigtrans;1999/5/re1

               (1999)."). In addition, NF-κB protects cells from the induction of programmed cell death by pro-apoptotic stimuli such as TNFα (refs [2](/articles/35019154#ref-CR2 "Beg, A. A. & Baltimore, D. Science 274, 782–784 (1996)."),[ 3](/articles/35019154#ref-CR3 "Liu, Z.-G, Hu, H., Goeddel, D. V. & Karin, M. Cell  87, 565–576 (1996).")). Another important anti-apoptotic signal-transducing protein is the protein kinase Akt (also known as protein kinase B), whose activity is strongly stimulated by growth factors[4](/articles/35019154#ref-CR4 "Hemmings, B. A.  Science 275, 628–630 ( 1997)."). Ozes _et al_.[5](/articles/35019154#ref-CR5 "Ozes, O. N.  et al. Nature 401, 82–85 (1999).") have suggested that Akt is involved in the TNFα-mediated activation of NF-κB[5](/articles/35019154#ref-CR5 "Ozes, O. N.  et al. Nature 401, 82–85 (1999)."), implying that some of the anti-apoptotic activity of Akt may be mediated through NF-κB. However, we have failed to detect any involvement of Akt in the signalling pathway through which TNFα leads to NF-κB activation.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Akt is not involved in IKK activation.

Similar content being viewed by others

References

  1. Rothwarf, D. M. & Karin, M. The NF-κ B Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus http://www.stke.org/cgi/content/fullOC_sigtrans;1999/5/re1 (1999).
  2. Beg, A. A. & Baltimore, D. Science 274, 782–784 (1996).
    Article ADS CAS Google Scholar
  3. Liu, Z.-G, Hu, H., Goeddel, D. V. & Karin, M. Cell 87, 565–576 (1996).
    Article CAS Google Scholar
  4. Hemmings, B. A. Science 275, 628–630 ( 1997).
    Article CAS Google Scholar
  5. Ozes, O. N. et al. Nature 401, 82–85 (1999).
    Article ADS CAS Google Scholar
  6. Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.-F & Verma, I. M. Science 284, 321–325 (1999).
    Article ADS CAS Google Scholar
  7. Hu, Y. et al. Science 284, 316–320 (1999).
    Article ADS CAS Google Scholar
  8. Takeda, K. et al. Science 284, 313–316 (1999).
    Article ADS CAS Google Scholar
  9. Delhase, M., Hayakawa, M., Chen, Y. & Karin, M. Science 284, 309–313 (1999).
    Article ADS CAS Google Scholar
  10. Tojima, Y. et al. Nature 404, 778–782 (2000).
    Article ADS CAS Google Scholar
  11. Sizemore, N., Leung, S. & Stark, G. R. Mol. Cell. Biol. 19, 4798– 4805 (1999).
    Article CAS Google Scholar
  12. Madrid, L. V. et al. Mol. Cell. Biol. 20, 1626– 1638 (2000).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0636, California, USA
    Mireille Delhase, Nanxin Li & Michael Karin

Authors

  1. Mireille Delhase
    You can also search for this author inPubMed Google Scholar
  2. Nanxin Li
    You can also search for this author inPubMed Google Scholar
  3. Michael Karin
    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toMichael Karin.

Rights and permissions

About this article

Cite this article

Delhase, M., Li, N. & Karin, M. Kinase regulation in inflammatory response .Nature 406, 367–368 (2000). https://doi.org/10.1038/35019154

Download citation