Toll-like receptors in the induction of the innate immune response (original) (raw)
Hoffmann, J. A., Kafatos, F. C., Janeway, C. A. & Ezekowitz, R. A. Phylogenetic perspectives in innate immunity. Science284, 1313–1318 (1999). ArticleADSCASPubMed Google Scholar
Aderem, A. & Underhill, D. M. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol.17, 593–623 (1999). ArticleCASPubMed Google Scholar
Janeway, C. A. Jr & Medzhitov, R. Introduction: the role of innate immunity in the adaptive immune response. Semin. Immunol.10, 349–350 ( 1998). Google Scholar
Ulevitch, R. J. & Tobias, P. S. Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr. Opin. Immunol.11, 19–22 (1999). ArticleCASPubMed Google Scholar
Darveau, R. P. Lipid A diversity and the innate host response to bacterial infection. Curr. Opin. Microbiol.1, 36–42 (1998). ArticleCASPubMed Google Scholar
Lien, E. et al. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J. Clin. Invest.105, 497–504 (2000). ArticleCASPubMedPubMed Central Google Scholar
Poltorak, A., Ricciardi-Castagnoli, P., Citterio, S. & Beutler, B. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation. Proc. Natl Acad. Sci. USA97, 2163–2167 (2000). ArticleADSCASPubMedPubMed Central Google Scholar
Henderson, B., Poole, S. & Wilson, M. Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiol. Rev.60, 316–341 (1996). ArticleCASPubMedPubMed Central Google Scholar
Brennan, P. J. & Nikaido, H. The envelope of mycobacteria. Annu. Rev. Biochem.64, 29 –63 (1995). ArticleCASPubMed Google Scholar
Kalambaheti, T., Bulach, D. M., Rajakumar, K. & Adler, B. Genetic organization of the lipopolysaccharide O-antigen biosynthetic locus of Leptospira borgpetersenii serovar Hardjobovis. Microb. Pathogen.27, 105–117 ( 1999). ArticleCAS Google Scholar
Mitchison, M. et al. Identification and characterization of the dTDP-rhamnose biosynthesis and transfer genes of the lipopolysaccharide-related rfb locus in Leptospira interrogans serovar Copenhageni. J. Bacteriol.179, 1262–1267 (1997). ArticleCASPubMedPubMed Central Google Scholar
Chaffin, W. L., Lopez-Ribot, J.L., Casanova, M., Gozalbo, D. & Martinez, J. P. Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Microbiol. Mol. Biol. Rev.62, 130– 180 (1998). ArticleCASPubMedPubMed Central Google Scholar
Tachado, S. D. et al. Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. Proc. Natl Acad. Sci. USA94, 4022–4027 (1997). ArticleADSCASPubMedPubMed Central Google Scholar
Descoteaux, A., Matlashewski, G. & Turco, S. J. Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania donovani lipophosphoglycan. J. Immunol.149, 3008–3015 (1992). CASPubMed Google Scholar
Ulevitch, R. J. & Tobias, P. S. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol.13, 437–457 ( 1995). ArticleCASPubMed Google Scholar
Schumann, R. R. et al. Structure and function of lipopolysaccharide binding protein . Science249, 1429–1431 (1990). ArticleADSCASPubMed Google Scholar
Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J. & Mathison, J. C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science249, 1431–1433 (1990). ArticleADSCASPubMed Google Scholar
Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M. & Hoffmann, J. A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell86, 973–983 ( 1996). ArticleCASPubMed Google Scholar
Williams, M. J., Rodriguez, A., Kimbrell, D. A. & Eldon, E. D. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J.16, 6120–6130 (1997). ArticleCASPubMedPubMed Central Google Scholar
Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science282, 2085 –2088 (1998). ArticleADSCASPubMed Google Scholar
Qureshi, S. T. et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189, 615– 625 (1999). [Erratum, J. Exp. Med. 189, following 1518 (1999)]. ArticleCASPubMedPubMed Central Google Scholar
Hoshino, K. et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product . J. Immunol.162, 3749– 3752 (1999). CASPubMed Google Scholar
Imler, J. L. & Hoffmann, J. A. Signaling mechanisms in the antimicrobial host defense of Drosophila. Curr. Opin. Microbiol.3, 16–22 (2000 ). ArticleCASPubMed Google Scholar
Anderson, K. V. Toll signaling pathways in the innate immune response. Curr. Opin. Immunol.12, 13–19 ( 2000). ArticleCASPubMed Google Scholar
Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A. Jr A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature388, 394–397 ( 1997). ArticleADSCASPubMed Google Scholar
Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A. & Bazan, J. F. A family of human receptors structurally related to Drosophila Toll. Proc. Natl Acad. Sci. USA95, 588–593 (1998). ArticleADSCASPubMedPubMed Central Google Scholar
Yang, R. B. et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature395, 284– 288 (1998). ArticleADSCASPubMed Google Scholar
Kirschning, C. J., Wesche, H., Merrill, A. T. & Rothe, M. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide . J. Exp. Med.188, 2091– 2097 (1998). ArticleCASPubMedPubMed Central Google Scholar
Underhill, D. M. et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature401, 811–815 (1999). ArticleADSCASPubMed Google Scholar
Heine, H. et al. Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J. Immunol.162, 6971–6975 (1999). CASPubMed Google Scholar
Shimazu, R. et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med.189, 1777–1782 (1999). ArticleCASPubMedPubMed Central Google Scholar
Flo, T. H. et al. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide . J. Immunol.164, 2064– 2069 (2000). ArticleCASPubMed Google Scholar
Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity11, 443–451 (1999). ArticleCASPubMed Google Scholar
Lien, E. et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem.274, 33419–33425 (1999). ArticleCASPubMed Google Scholar
Takeuchi, O. et al. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor. J. Immunol.164, 554 –557 (2000). ArticleCASPubMed Google Scholar
Hirschfeld, M. et al. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol.163, 2382–2386 ( 1999). CASPubMed Google Scholar
Ohashi, K., Burkart, V., Flohe, S. & Kolb, H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol.164, 558– 561 (2000). ArticleCASPubMed Google Scholar
Means, T. K. et al. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J. Immunol.163, 6748–6755 ( 1999). CASPubMed Google Scholar
Means, T. K. et al. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol.163, 3920–3927 (1999). CASPubMed Google Scholar
Brightbill, H. D. et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science285, 732–736 (1999). ArticleCASPubMed Google Scholar
Underhill, D. M., Ozinsky, A., Smith, K. D. & Aderem, A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl Acad. Sci. USA96, 14459–14463 (1999). ArticleADSCASPubMedPubMed Central Google Scholar
Chaudhary, P. M. et al. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood91, 4020–4027 ( 1998). ArticleCASPubMed Google Scholar
Takeuchi, O. et al. TLR6: a novel member of an expanding toll-like receptor family . Gene231, 59–65 (1999). ArticleCASPubMed Google Scholar
Levashina, E. A. et al. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science285, 1917–1919 (1999). ArticleCASPubMed Google Scholar
Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell2, 253– 258 (1998). ArticleCASPubMed Google Scholar
Yang, R. B., Mark, M. R., Gurney, A. L. & Godowski, P. J. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J. Immunol.163, 639– 643 (1999). CASPubMed Google Scholar
Muzio, M., Natoli, G., Saccani, S., Levrero, M. & Mantovani, A. The human toll signaling pathway: divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med.187, 2097–2101 (1998). ArticleCASPubMedPubMed Central Google Scholar
Medzhitov, R. & Janeway, C. Jr Innate immune recognition: mechanisms and pathways. Immunol. Rev.173, 89–97 (2000). ArticleCASPubMed Google Scholar
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity7, 837–847 (1997). ArticleCASPubMed Google Scholar
Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. & Goeddel, D. V. TRAF6 is a signal transducer for interleukin-1. Nature383, 443–446 ( 1996). ArticleADSCASPubMed Google Scholar
Ninomiya-Tsuji, J. et al. The kinase TAK1 can activate the NIK-I κB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature398, 252–256 (1999). ArticleADSCASPubMed Google Scholar
Kopp, E. et al. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev.13, 2059–2071 (1999). ArticleCASPubMedPubMed Central Google Scholar
Irie, T., Muta, T. & Takeshige, K. TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-κB in lipopolysaccharide-stimulated macrophages. FEBS Lett.467, 160–164 (2000). ArticleCASPubMed Google Scholar
Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin . Immunity11, 115–122 (1999). ArticleCASPubMed Google Scholar
Lomaga, M. A. et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev.13, 1015–1024 (1999). ArticleCASPubMedPubMed Central Google Scholar
Thomas, J. A. et al. Impaired cytokine signaling in mice lacking the IL-1 receptor- associated kinase. J. Immunol.163, 978– 984 (1999). CASPubMed Google Scholar
Wesche, H. et al. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem.274, 19403–19410 (1999). ArticleCASPubMed Google Scholar