A chemical switch for inhibitor-sensitive alleles of any protein kinase (original) (raw)

• Gray, N. S. et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281, 533–538 (1998).
  Article ADS CAS Google Scholar
• Bishop, A. C. et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 121, 627–631 (1999).
  Article CAS Google Scholar
• Reed, S. I. The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95, 561– 577 (1980).
  CAS PubMed PubMed Central Google Scholar
• Liu, Y., Shah, K., Yang, F., Witucki, L. & Shokat, K. M. Engineering Src family protein kinases with unnatural nucleotide specificity. Chem. Biol. 5, 91 –101 (1998).
  Article CAS Google Scholar
• Hanke, J. H. et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. J. Biol. Chem. 271, 695 –701 (1996).
  Article CAS Google Scholar
• Brown, M. T. & Cooper, J. A. Regulation, substrates and functions of src. Biochim. Biophys. Acta 1287, 121 –149 (1996).
  PubMed Google Scholar
• Resh, M. D. Fyn, a Src family tyrosine kinase. Int. J. Biochem. Cell Biol. 30, 1159–1162 ( 1998).
  Article CAS Google Scholar
• Laneuville, P. Abl tyrosine protein kinase. Semin. Immunol. 7, 255–266 (1995).
  Article CAS Google Scholar
• Kelly, P. T. Calmodulin-dependent protein kinase II. Multifunctional roles in neuronal differentiation and synaptic plasticity. Mol. Neurobiol. 5, 153–177 (1991).
  Article CAS Google Scholar
• Morgan, D. O. Principles of CDK regulation. Nature 374, 131–134 (1995).
  Article ADS CAS Google Scholar
• Lawrie, A. M. et al. Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2. Nature Struct. Biol. 4, 796–801 (1997).
  Article CAS Google Scholar
• Wood, J. L., Stoltz, B. M., Dietrich, H. J., Pflum, D. A. & Petsch, D. T. Design and implementation of an efficient synthetic approach to furanosylated indolocarbazoles: total synthesis of (+)- and (-)-K252a. J. Am. Chem. Soc. 119, 9641–9651 (1997).
  Article CAS Google Scholar
• Liu, Y. et al. Structural basis for selective inhibition of Src family kinases by PP1. Chem. Biol. 6, 671– 678 (1999).
  Article CAS Google Scholar
• Hunter, T. & Plowman, G. D. The protein kinases of budding yeast: six score and more. Trends Biochem. Sci. 22, 18–22 (1997).
  Article CAS Google Scholar
• Fujimura, H. A. Yeast homolog of mammalian mitogen-activated protein kinase, Fus3/Dac2 kinase, is required both for cell fusion and for G1 arrest of the cell cycle and morphological changes by the cdc37 mutation. J. Cell. Sci. 107, 2617–2622 (1994).
  CAS PubMed Google Scholar
• Doi, S. & Yoshimura, M. Temperature-sensitive loss of sexual agglutinability in Saccharomyces cerevisiae. Arch. Microbiol. 114, 287–288 (1977).
  Article CAS Google Scholar
• Mendenhall, M. D. & Hodge, A. E. Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62, 1191–1243 ( 1998).
  CAS PubMed PubMed Central Google Scholar
• King, R. W., Jackson, P. K. & Kirschner, M. W. Mitosis in transition. Cell 79, 563–571 (1994).
  Article CAS Google Scholar
• Surana, U. et al. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65, 145 –161 (1991).
  Article CAS Google Scholar
• Bourne, Y. et al. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell 84, 863–874 ( 1996).
  Article CAS Google Scholar
• Wodicka, L., Dong, H., Mittmann, M., Ho, M. H. & Lockhart, D. J. Genome-wide expression monitoring in Saccharomyces cerevisiae. Nature Biotechnol. 15, 1359 –1367 (1997).
  Article CAS Google Scholar
• Espinoza, F. H., Ogas, J., Herskowitz, I. & Morgan, D. O. Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science 266, 1388–1391 ( 1994).
  Article ADS CAS Google Scholar
• Spellman, P. T. et al. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 9, 3273– 3297 (1998).
  Article CAS Google Scholar
• Fitch, I. et al. Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 3, 805–818 (1992).
  Article CAS Google Scholar
• Stern, B. & Nurse, P. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 12, 345–350 ( 1996).
  Article CAS Google Scholar
• Farrell, A. & Morgan, D. O. Cdc37 promotes the stability of protein kinases Cdc28 and Cak1. Mol. Cell. Biol. 20 , 749–754 (2000).
  Article CAS Google Scholar
• Sherman, F., Fink, G. & Lawrence, C. Methods in Yeast Genetics (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1974).
  Google Scholar
• Sikorski, R. S. & Hieter, P. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19–27 (1989).
  CAS PubMed PubMed Central Google Scholar
• Schindler, T. et al. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol. Cell 3, 639–648 (1999).
  Article CAS Google Scholar
• Biggins, S. et al. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev. 13, 532–544 (1999).
  Article CAS Google Scholar