Development of a preventive vaccine for Ebola virus infection in primates (original) (raw)

• Feldmann, H., Nichol, S. T., Klenk, H. D., Peters, C. J. & Sanchez, A. Characterization of filoviruses based on differences in structure and antigenicity of the virion glycoprotein. Virology 199, 469–473 (1994).
  Article CAS Google Scholar
• Sanchez, A., Trappier, S. G., Mahy, B. W. J., Peters, C. J. & Nichol, S. T. The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc. Natl Acad. Sci. USA 93, 3602–3607 (1996).
  Article ADS CAS Google Scholar
• Tang, D. C., DeVit, M. & Johnston, S. A. Genetic immunization is a simple method for eliciting an immune response. Nature 356, 152–154 (1992).
  Article ADS CAS Google Scholar
• Ulmer, J. B. et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745–1749 (1993).
  Article ADS CAS Google Scholar
• Wang, B. et al. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl Acad. Sci. USA 90, 4156–4160 (1993).
  Article ADS CAS Google Scholar
• Sedegah, M., Hedstrom, R., Hobart, P. & Hoffman, S. L. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl Acad. Sci. USA 91, 9866–9870 (1994).
  Article ADS CAS Google Scholar
• Krieg, A. M. et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546–549 (1995).
  Article ADS CAS Google Scholar
• Sato, Y. et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352–354 (1996).
  Article ADS CAS Google Scholar
• Xu, L. et al. Immunization for Ebola virus infection. Nature Med. 4, 37–42 (1998).
  Article CAS Google Scholar
• Vanderzanden, L. et al. DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge. Virology 246, 134–144 (1998).
  Article CAS Google Scholar
• Connolly, B. M. et al. Pathogenesis of experimental Ebola virus infection in guinea pigs. J. Infect. Dis. 179, S203–S217 (1999).
  Article Google Scholar
• Bray, M., Davis, K., Geisbert, T., Schmaljohn, C. & Huggins, J. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178, 651–661 (1998).
  Article CAS Google Scholar
• Baize, S. et al. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nature Med. 5, 423–426 (1999).
  Article CAS Google Scholar
• Maruyama, T. et al. Ebola virus can be effectively neutralized by antibody produced in natural human infection. J. Virol. 73, 6024–6030 (1999).
  CAS PubMed PubMed Central Google Scholar
• Sedegah, M. et al. Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine. Proc. Natl Acad. Sci. USA 95, 7648–7653 (1998).
  Article ADS CAS Google Scholar
• Hanke, T. et al. Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime. Vaccine 16, 439–445 (1998).
  Article ADS CAS Google Scholar
• Robinson, H. L. et al. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations. Nature Med. 5, 526–534 (1999).
  Article CAS Google Scholar
• Schneider, J. et al. Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nature Med. 4, 397–402 (1998).
  Article CAS Google Scholar
• Davis, A. R. et al. Expression of hepatitis B surface antigen with a recombinant adenovirus. Proc. Natl Acad. Sci. USA 82, 7560–7564 (1985).
  Article ADS CAS Google Scholar
• Natuk, R. J. et al. Adenovirus-human immunodeficiency virus (HIV) envelope recombinant vaccines elicit high-titered HIV-neutralizing antibodies in the dog model. Proc. Natl Acad. Sci. USA 89, 7777–7781 (1992).
  Article ADS CAS Google Scholar
• Xiang, Z. Q., Yang, Y., Wilson, J. M. & Ertl, H. C. A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier. Virology 219, 220–227 (1996).
  Article CAS Google Scholar
• Xiang, Z. Q., Pasquini, S. & Ertl, H. C. Induction of genital immunity by DNA priming and intranasal booster immunization with a replication-defective adenoviral recombinant. J. Immunol. 162, 6716–6723 (1999).
  CAS PubMed Google Scholar
• Letvin, N. L. et al. Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination. Proc. Natl Acad. Sci. USA 94, 9378–9383 (1997).
  Article ADS CAS Google Scholar
• Fisher-Hoch, S. P. et al. Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola). J. Infect. Dis. 152, 887–894 (1985).
  Article CAS Google Scholar
• Wilson, J. et al. Epitopes involved in antibody-mediated protection from Ebola virus. Science 287, 1664–1666 (2000).
  Article ADS CAS Google Scholar
• Ohno, T. et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science 265, 781–784 (1994).
  Article ADS CAS Google Scholar
• Aoki, K., Barker, C., Danthinne, X., Imperiale, M. J. & Nabel, G. J. Efficient generation of recombinant adenoviral vectors by Cre-lox recombination in vitro. Mol. Med. 5, 224–231 (1999).
  Article CAS Google Scholar
• Ksiazek, T. G. et al. Enzyme immunosorbent assay for Ebola virus antigens in tissues of infected primates. J. Clin. Microbiol. 30, 947–950 (1992).
  CAS PubMed PubMed Central Google Scholar
• Kiley, M. P., Regnery, R. L. & Johnson, K. M. Ebola virus: identification of virion structural proteins. J. Gen. Virol. 49, 333–341 (1980).
  Article CAS Google Scholar