Coenzyme Q is an obligatory cofactor for uncoupling protein function (original) (raw)

• Nicholls, D. G. & Locke, R. M. Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1–64 (1984).
  Article CAS Google Scholar
• Klingenberg, M. & Huang, S.-G. Structure and function of the uncoupling protein from brown adipose tissue. Biochim. Biophys. Acta 1415, 271–296 (1999).
  Article CAS Google Scholar
• Nedergaard, J. & Cannon, B. The uncoupling portein thermogenin and mitochondrial thermogenesis. New Comp. Biochem. 23, 385–420 (1992).
  Article CAS Google Scholar
• Fleury, C. et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genet. 15, 269–272 (1997).
  Article CAS Google Scholar
• Boss, O. et al. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408, 39–42 (1997).
  Article ADS CAS Google Scholar
• Mao, W. et al. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 43, 326–330 (1999).
  Article Google Scholar
• Laloi, M. et al. Plant cold-induced uncoupling protein. Nature 389, 135–136 (1997).
  Article ADS CAS Google Scholar
• Boss, O., Muzzin, P. & Giacobino, J. P. The uncoupling proteins, a review. Eur. J. Endocrinol. 139, 1–9 (1998).
  Article CAS Google Scholar
• Ricquier, D. & Bouillaud, F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem. J. 345, 161–179 (2000).
  Article CAS Google Scholar
• Aquila, H., Link, T. A. & Klingenberg, M. Solute carriers involved in energy transfer of mitochondria form a homologous protein family. FEBS Lett. 212, 1–9 (1987).
  Article CAS Google Scholar
• Lin, C. S. & Klingenberg, M. Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria. Biochemistry 21, 2950–2956 (1982).
  Article CAS Google Scholar
• Jezek, P., Orosz, D. E., Modriansky, M. & Garlid, K. D. Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids. A new look at old hypotheses. J. Biol. Chem. 269, 26184–26190 (1994).
  CAS PubMed Google Scholar
• Gonzalez-Barroso, M. M., Fleury, C., Bouillaud, F., Nicholls, D. G. & Rial, E. The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. J. Biol. Chem. 273, 15528–15532 (1998).
  Article CAS Google Scholar
• Matthias, A., Jacobsson, A., Cannon, B. & Nedergaard, J. The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization (“uncoupling”). J. Biol. Chem. 274, 28150–28160 (1999).
  Article CAS Google Scholar
• Echtay, K. S. et al. Regulation of UCP3 by nucleotides is different from regulation of UCP1. FEBS Lett. 450, 8–12 (1999).
  Article CAS Google Scholar
• Murdza-Inglis, D. L. et al. Functional reconstitution of rat uncoupling protein following its high level expression in yeast. J. Biol. Chem. 266, 11871–11875 (1991).
  CAS PubMed Google Scholar
• Arechaga, I. et al. Cysteine residues are not essential for uncoupling protein function. Biochem. J. 296, 693–700 (1993).
  Article CAS Google Scholar
• Echtay, K. S., Bienengraeber, M. & Klingenberg, M. Mutagenesis of the uncoupling protein of brown adipose tissue. Neutralization of E190 largely abolishes pH control of nucleotide binding. Biochemistry 36, 8253–8260 (1997).
  Article CAS Google Scholar
• Bathgate, B., Freebairn, E. M., Greenland, A. J. & Reid, G. A. Functional expression of the rat brown adipose tissue uncoupling protein in Saccharomyces cerevisiae. Mol. Microbiol. 6, 363–370 (1992).
  Article CAS Google Scholar
• Jaburek, M. et al. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J. Biol. Chem. 274, 26003–26007 (1999).
  Article CAS Google Scholar
• Huang, S.-G. & Klingenberg, M. Fluorescent nucleotide derivatives as specific probes for the uncoupling protein: thermodynamics and kinetics of binding and the control by pH. Biochemistry 34, 349–360 (1995).
  Article CAS Google Scholar
• Winkler, E., Wachter, E. & Klingenberg, M. Identification of the pH sensor for nucleotide binding in the uncoupling protein from brown adipose tissue. Biochemistry 36, 148–155 (1997).
  Article CAS Google Scholar
• Skulachev, V. P. Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation. FEBS Lett. 294, 158–162 (1991).
  Article CAS Google Scholar
• Brustovetsky, N. & Klingenberg, M. The reconstituted ADP/ATP carrier can mediate H+ transport by free fatty acids, which is further stimulated by mersalyl. J. Biol. Chem. 269, 27329–27336 (1994).
  CAS PubMed Google Scholar
• Winkler, E. & Klingenberg, M. Effect of fatty acids on H+ transport activity of the reconstituted uncoupling protein. J. Biol. Chem. 269, 2508–2515 (1994).
  CAS PubMed Google Scholar
• Fiermonte, G., Walker, J. & Palmieri, F. Abundant bacterial expression and reconstitution of an intrinsic membrane transport protein from bovine mitochondria. Biochem. J. 294, 293–299 (1993).
  Article CAS Google Scholar
• Kaplan, R. S. High-level bacterial expression of mitochondrial transport proteins. J. Bioenerg. Biomembr. 28, 41–47 (1996).
  Article CAS Google Scholar
• Schroers, A., Burkovski, A., Wohlrab, H. & Kramer, R. The phosphate carrier from yeast mitochondria. Dimerization is a prerequisite for function. J. Biol. Chem. 273, 14269–14276 (1998).
  Article CAS Google Scholar
• Kowaltowski, A. J., Costa, A. D. & Vercesi, A. E. Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. FEBS Lett. 425, 213–216 (1998).
  Article CAS Google Scholar
• Walter, L. et al. Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site. J. Biol. Chem. 275, 29521–29527 (2000).
  Article CAS Google Scholar